141708-85-2Relevant academic research and scientific papers
Evaluation of Zard trifluoromethylketone synthesis for the preparation of potential bifunctional fluorinated synthons
Diter, Patrick,Magnier, Emmanuel,Blazejewski, Jean-Claude
, p. 1235 - 1240 (2007)
In the quest for potential bifunctional fluorinated synthons, we examined the behavior of chlorodifluoroacetic and hexafluoroglutaric anhydride in their reaction with acid chlorides in the presence of pyridine under the conditions of Zard trifluoromethylketone synthesis. Chlorodifluoroacetic anhydride led easily to the expected chlorodifluoromethyl ketones in the case of relatively non-encumbered primary acid chlorides. In the case of hexafluoroglutaric anhydride we observed the unexpected formation of α substituted hexafluorocyclohexane-1,3-dione derivatives among with the corresponding fluorinated 3-chloro-cyclohexenones.
The Wittig Reaction of Perfluoro Acid Derivatives: Access to Fluorinated Enol Ethers, Enamines, and Ketones
Begue, Jean-Pierre,Bonnet-Delpon, Daniele,Mesureur, Dany,Nee, Gerard,Wu, Sheng-Wen
, p. 3807 - 3814 (2007/10/02)
The preparation of novel perfluoroalkyl-substituted compounds in good yields is described.This preparation involves the Wittig reaction of a phosphonium ylide with perfluoroalkyl acid derivatives.The influence of the structure of the starting alkylidenetr
