1417340-85-2Relevant academic research and scientific papers
General and efficient copper-catalyzed aerobic oxidative synthesis of N-fused heterocycles using amino acids as the nitrogen source
Liu, Qing,Yang, Haijun,Jiang, Yuyang,Zhao, Yufen,Fu, Hua
, p. 15636 - 15644 (2013/09/12)
A general and efficient copper-catalyzed aerobic oxidative method for the synthesis of N-fused heterocycles has been developed by using readily available α-amino acids as the nitrogen source. The reactions underwent N-arylation, aerobic oxidative dehydrogenation, intramolecular cyclization and dissociation of formic acid. This method should provide a general and practical strategy for the construction of N-fused heterocycles.
Synthesis of pyrazolo[1,5- c ]quinazoline derivatives through copper-catalyzed tandem reaction of 5-(2-bromoaryl)-1 H -pyrazoles with carbonyl compounds and aqueous ammonia
Guo, Shenghai,Wang, Jiliang,Fan, Xuesen,Zhang, Xinying,Guo, Dongqiang
, p. 3262 - 3270 (2013/06/26)
A practical and efficient synthesis of pyrazolo[1,5-c]quinazolines and 5,6-dihydropyrazolo[1,5-c]quinazolines, including several spiro compounds, through copper-catalyzed tandem reaction of 5-(2-bromoaryl)-1H-pyrazoles with carbonyl compounds and aqueous ammonia under air has been developed. Compared with literature methods toward pyrazolo[1,5-c]quinazoline derivatives, the synthetic method reported in this paper has the advantages of readily available and inexpensive starting materials and reagents, broad scope of substrates, and mild reaction conditions.
