1417453-14-5

Basic information

• Product Name: 2’,4’-diisopropoxy-3,4-dimethoxychalcone
• Synonyms: 2’,4’-diisopropoxy-3,4-dimethoxychalcone
• CAS NO: 1417453-14-5
• Molecular Weight: 384.472
• Mol File: 1417453-14-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2’,4’-diisopropoxy-3,4-dimethoxychalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 2’,4’-diisopropoxy-3,4-dimethoxychalcone(1417453-14-5)
• EPA Substance Registry System: 2’,4’-diisopropoxy-3,4-dimethoxychalcone(1417453-14-5)

Safety Data

• Hazardous Substances Data: 1417453-14-5(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 728911-59-9 2,4-diisopropoxyacetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Downstream Products

• 104236-80-8 2′,4′-dihydroxy-3,4-dimethoxychalcone 

Relevant articles and documents

Reactivity assessment of chalcones by a kinetic thiol assay

The electrophilic nature of chalcones (1,3-diphenylprop-2-en-1-ones) and many other α,β-unsaturated carbonyl compounds is crucial for their biological activity, which is often based on thiol-mediated regulation processes. To better predict their biological activity a simple screening assay for the assessment of the second-order rate constants (k2) in thia-Michael additions was developed. Hence, a clear structure-activity relationship of 16 differentially decorated hydroxy-alkoxychalcones upon addition of cysteamine could be established. Moreover, amongst other naturally occurring α,β-unsaturated carbonyl compounds k2 values for curcumin and cinnamaldehyde were gained while cinnamic acids or esters gave no or very slow reactions.