1417456-04-2

Basic information

• Product Name: 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride
• Synonyms: 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride;2-aMino-6-fluoro-N-phenylbenzaMide;2-Fluoro-6-amino-N-phenylbenzamide
• CAS NO: 1417456-04-2
• Molecular Formula: C13H11FN2O
• Molecular Weight: 230.2376432
• Mol File: 1417456-04-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 320.8±32.0 °C(Predicted)
• Appearance: /
• Density: 1.317±0.06 g/cm3(Predicted)
• PKA: 12.37±0.70(Predicted)
• CAS DataBase Reference: 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride(1417456-04-2)
• EPA Substance Registry System: 2-aMino-6-fluoro-N-phenylbenzaMide hydrochloride(1417456-04-2)

Safety Data

• Hazardous Substances Data: 1417456-04-2(Hazardous Substances Data)

Usage

Uses

2-Amino-6-fluoro-N-phenylbenzamide is used as reactant/reagent in synthetic preparation of idelalisib using the HMDS/I2-catalyzed cyclocondensation and Boc deprotection of an (aminobutyrylamino)benzamide to a nonracemic quinazoline as the key step. 2-Amino-6-fluoro-N-phenyl-benzamide is obtained from 2-fluoro-6-nitro-benzoic acid.

Upstream product

• 434-76-4 2-amino-6-fluorobenzoic acid 

Downstream Products

• 1615255-70-3 (S)-2-(1-aminoethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one 
• 1615254-09-5 (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF AMORPHOUS IDELALISIB AND ITS PREMIX

Processes for the preparation of amorphous idelalisib are provided. Processes for the preparation of a premix of amorphous idelalisib are also provided.