141746-36-3Relevant academic research and scientific papers
SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS
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, (2008/06/13)
This invention relates to compounds having selective LTB 4 antagonist properties, compositions comprising said compounds and methods for the treatment of disorders involving LTB 4 agonist-mediated activity utilizing said compositions wherein the compounds
ω-alkanoic Acid Derivatives: A New Family of Potent and Orally Active LTB4 Antagonists
Labaudiniere, Richard,Dereu, Norbert,Cavy, Francois,Guillet, Marie-Christine,Marquis, Olivier,Terlain, Bernard
, p. 4315 - 4324 (2007/10/02)
A series of ω-alkanoic acid derivatives was prepared which inhibited the binding of leukotriene B4 to its receptors on guinea pig spleen membranes and on human polymorphonuclear leukocytes (PMNs) and selectively ant
