141750-59-6

Basic information

• Product Name: (3S,5R,6E)-7-<2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>-3,5-dihydroxy-6-heptenoic acid ,15-lactone
• CAS NO: 141750-59-6
• Molecular Weight: 403.453
• Mol File: 141750-59-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3S,5R,6E)-7-<2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>-3,5-dihydroxy-6-heptenoic acid ,15-lactone(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5R,6E)-7-<2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>-3,5-dihydroxy-6-heptenoic acid ,15-lactone(141750-59-6)
• EPA Substance Registry System: (3S,5R,6E)-7-<2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>-3,5-dihydroxy-6-heptenoic acid ,15-lactone(141750-59-6)

Safety Data

• Hazardous Substances Data: 141750-59-6(Hazardous Substances Data)

Upstream product

• 146578-99-6 <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methyl(diphenyl)phosphine oxide 
• 154057-56-4 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline 
• 254452-86-3 (E)-(3S,5R)-7-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid 
• 146579-01-3 ((4S,6R)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid methyl ester 

Relevant articles and documents

A novel enantioselective synthesis of HMG Co-A reductase inhibitor NK-104 and a related compound

Optically active methyl 6-oxo-3,5-syn-isopropylidenedioxyhexanoate (5) was prepared by enantioselective syn-reduction of β,δ-diketo ester 2, followed by hydrolysis, protection of the diol moiety and ozonolysis, and was converted into a highly potent HMG Co-A reductase inhibitor NK-104 and an analogue.

Optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids

The present invention provides optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids represented by the following formula: STR1 wherein R is a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroarom