1417524-82-3Relevant academic research and scientific papers
One-pot copper-catalyzed three-component synthesis of quinoxalines by condensation and C-N bond formation
Yuan, Hua,Li, Kangning,Chen, Yongxin,Wang, Yu,Cui, Jiaojiao,Chen, Baohua
, p. 2315 - 2319 (2013)
A novel way of synthesizing quinoxalines has been developed that involves condensation and C-N bond formation in a copper-catalyzed, one-pot, three-component reaction. The reaction was optimized when 2-iodoanilines (1.0 equiv), arylacetaldehydes (2.0 equiv), sodium azide (1.2 equiv), CuI (10 mol%), DMEDA (10 mol%), and K2CO3 (1.0 equiv) were reacted in DMSO at 80 °C for 20 hours. This approach was used to directly synthesize a variety of quinoxalines in moderate to good yields. Georg Thieme Verlag KG Stuttgart.
A catalyst free, one pot approach for the synthesis of quinoxaline derivatives via oxidative cyclisation of 1,2-diamines and phenacyl bromides
Kumar, Kapil,Mudshinge, Sagar Ravso,Goyal, Sandeep,Gangar, Mukesh,Nair, Vipin A.
supporting information, p. 1266 - 1271 (2015/03/04)
A simple, efficient and eco-friendly method has been developed for quinoxaline synthesis from inexpensive and readily available diamines and phenacyl bromides by catalyst- and additive-free protocol.
Transition-metal-free synthesis of quinoxalines from o-phenylenediamines and arylacetaldehydes under basic conditions
Song, Jinli,Li, Xiaolong,Chen, Yongxin,Zhao, Mingming,Dou, Yani,Chen, Baohua
supporting information, p. 2416 - 2420 (2013/07/19)
A novel method for the synthesis of quinoxalines via transition-metal-free cyclization of o-phenylenediamine and arylacetaldehyde in a one-pot procedure has been developed. In this process, an inorganic base (K2CO 3) is the only reagent required, and it proceeds smoothly in the absence of adding transition metal catalysts. The reaction appears to be very general and suitable for the construction of a variety of quinoxalines. Georg Thieme Verlag Stuttgart. New York.
