1417547-50-2Relevant articles and documents
Enantioselective titanium(III)-catalyzed reductive cyclization of ketonitriles
Streuff, Jan,Feurer, Markus,Bichovski, Plamen,Frey, Georg,Gellrich, Urs
, p. 8661 - 8664 (2012/09/21)
Reduction, please! The title reaction affords ?-hydroxyketones, a common structural motif in biologically active natural products, in good yields and high enantioselectivities at room temperature. The commercially available ansa-titanocene 1 was found to be an efficient catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.
