141764-83-2

Upstream product

• 186581-53-3 diazomethane 
• 71088-82-9 2-ethyl-3-furoic acid 
• 141764-78-5 2-Ethyl-5-phenylsulfanyl-4,5-dihydro-furan-3-carboxylic acid methyl ester 
• 856676-55-6 methyl 2-vinyl-3-furoate 
• 53020-08-9 2-bromomethylfuran-3-carboxylic acid methyl ester 
• 6141-58-8 methyl 2-methyl-3-furancarboxylate 
• 6947-94-0 2-methyl-3-furancarboxylic acid 
• 30414-53-0 methyl propanoyl acetate 
• 141764-72-9 2-(2-Benzenesulfinyl-ethyl)-3-oxo-pentanoic acid methyl ester 
• 67-56-1 methanol 

Downstream Products

• 1334598-68-3 C₁₅H₁₄O₄ 
• 1334598-76-3 C₁₄H₁₄O₅S 
• 1334598-80-9 C₁₄H₁₃NO₄ 
• 1334598-45-6 C₁₆H₁₆O₄ 
• 1334598-53-6 C₁₅H₁₆O₅S 
• 1334598-57-0 C₁₅H₁₅NO₄ 
• 1334598-09-2 C₂₁H₂₀N₂O₃S 
• 1334598-10-5 C₂₂H₂₂N₂O₃S 
• 1334598-22-9 C₂₀H₂₀N₂O₄S₂ 
• 1334598-26-3 C₂₀H₁₉N₃O₃S 

Relevant academic research and scientific papers

Discovery and hit-to-lead optimization of novel allosteric glucokinase activators

We report on a hit generation and hit-to-lead program of a novel class of glucokinase activators (GKAs). Hit compounds, activators at low glucose concentration only were identified by vHTS. Scaffold modification reliably afforded activators also at high s

New methodology for 2-alkylation of 3-furoic acids: Application to the synthesis of tethered UC-781/d4T bifunctional HIV reverse-transcriptase inhibitors

New methodology for 2-alkylation of 3-furoic acids is presented involving Wittig reactions of the 3-methoxycarbonyl-2-furanylmethylphosphonium salt. The methodology has been used to prepare a tethered 2-alkylated-UC-781/d4T conjugate as a potentially new type of HIV reverse-transcriptase inhibitor.

An Improved Synthesis of 2-Substituted-3-furoic Acids Leading to an Intramolecular Diels-Alder Reaction Between a Dienophile and Furan Diene Both Containing an Electron Withdrawing Group

An improved preparation of various 2-substituted-3-furoic acids by lithiation of 2-methyl-3-furoic acid with 2.0 equiv. of butyllithium, and a successful intramolecular Diels-Alder reaction using 0.1 equiv. of methylaluminium dichloride between a dienophi

Unsaturated Sulfoxides in Organic Synthesis: A New General Furan Synthesis

Furans have been efficiently synthesised by a three-step reaction sequence.Michael addition of keto esters to alkenyl sulfoxides followed by Pummerer rearrangement afforded the cyclic intermediates 11 in good yield.Treatment of the latter with 3-chloroperoxybenzoic acid led by oxidation and syn-elimination of the corresponding sulfoxide, to substituted furans.