1417654-15-9

Basic information

• Product Name: (S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide
• Synonyms: (S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide
• CAS NO: 1417654-15-9
• Molecular Weight: 623.229
• Mol File: 1417654-15-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide(1417654-15-9)
• EPA Substance Registry System: (S)-N-(2-amino-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propyl)morpholine-4-carboxamide(1417654-15-9)

Safety Data

• Hazardous Substances Data: 1417654-15-9(Hazardous Substances Data)

Upstream product

• 15159-40-7 4-morpholinocarbonyl chloride 
• 1417654-04-6 (S)-tert-butyl (1-amino-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate 
• 1417654-03-5 (S)-tert-butyl (1-azido-3-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)propan-2-yl)carbamate 
• 1417654-02-4 (S)-tert-butyl (1-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)-3-((diphenoxyphosphoryl)oxy)propan-2-yl)carbamate 
• 1417654-01-3 (S)-tert-butyl (1-(3,5-diiodo-4-(4-((4-methoxybenzyl)oxy)phenoxy)phenyl)-3-hydroxypropan-2-yl)carbamate 
• 1417654-00-2 (S)-tert-butyl (1-hydroxy-3-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)propan-2-yl)carbamate 
• 1428317-56-9 C₃₃H₃₉I₂N₃O₇ 
• 1041-01-6 3,5-diiodo-L-thyronine 

Relevant articles and documents

Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis

Proliferating cell nuclear antigen (PCNA) is an essential component for DNA replication and DNA damage response. Numerous proteins interact with PCNA through their short sequence called the PIP-box to be promoted to their respective functions. PCNA supports translesion DNA synthesis (TLS) by interacting with TLS polymerases through PIP-box interaction. Previously, we found a novel small molecule inhibitor of the PCNA/PIP-box interaction, T2AA, which inhibits DNA replication in cells. In this study, we created T2AA analogues and characterized them extensively for TLS inhibition. Compounds that inhibited biochemical PCNA/PIP-box interaction at an IC50 a reporter plasmid that was globally damaged by cisplatin, suggesting that the inhibitors blocked the TLS that allows replication of the plasmid. PCNA inhibitors increased γH2AX induction and cell viability reduction mediated by cisplatin. Taken together, these findings suggest that inhibitors of PCNA/PIP-box interaction could chemosensitize cells to cisplatin by inhibiting TLS.