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1417658-40-2

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1417658-40-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1417658-40-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,7,6,5 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1417658-40:
(9*1)+(8*4)+(7*1)+(6*7)+(5*6)+(4*5)+(3*8)+(2*4)+(1*0)=172
172 % 10 = 2
So 1417658-40-2 is a valid CAS Registry Number.

1417658-40-2Downstream Products

1417658-40-2Relevant articles and documents

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents

Wang, Hai-Hong,Qiu, Ke-Ming,Cui, Hong-En,Yang, Yu-Shun,Yin-Luo,Xing, Man,Qiu, Xiao-Yang,Bai, Li-Fei,Zhu, Hai-Liang

, p. 448 - 455 (2013/02/25)

A series of novel thiazolyl-pyrazoline derivatives containing benzodioxole (C1-C20) have been designed and synthesized. Among of the synthesized compounds, 2-(5-(benzo[d][1,3]dioxol-5-yl)-3-(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)- 4-(4-bromophenyl)thiazole (C6) displayed the most potent inhibitory activity for HER-2 (IC50 = 0.18 μM for HER-2). Antiproliferative assay results indicated that compound C6 owned high antiproliferative activity against MCF-7 and B16-F10 in vitro, with IC50 value of 0.09 and 0.12 μM, respectively, being comparable with the positive control Erlotinib. Docking simulation was further performed to determine the probable binding model. Based on the preliminary results, compound C6 with potent inhibitory activity in tumor growth would be a potential anticancer agent.

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