141774-20-1 Usage
Description
NPC-15437 (141774-20-1) is a potent and selective inhibitor of protein kinase C which binds to the regulatory domain (IC50=19 μM).1,2 It specifically interacts with the C1 domain of PKC.3 Important tool for assessing the role of PKC in various signaling pathways.4??Cell permeable.?Active?in vivo.4
Uses
N 161 is a selective protein kinase C (PKC) inhibitor. PKC is involved with signal transduction cascades related to immune response, cell growth, and memory.
References
References/Citations
1) Sullivan et al. (1992), 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain; Mol. Pharmacol., 41 38
2) Sullivan et al. (1991), 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C; Agents Actions 34 142
3) Sullivan et al. (1991), NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs; FEBS Lett., 285 120
4) Miyoshi et al. (2007), mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption; Eur. J. Pharmacol., 562 208
Check Digit Verification of cas no
The CAS Registry Mumber 141774-20-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,7,7 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 141774-20:
(8*1)+(7*4)+(6*1)+(5*7)+(4*7)+(3*4)+(2*2)+(1*0)=121
121 % 10 = 1
So 141774-20-1 is a valid CAS Registry Number.
141774-20-1Relevant articles and documents
Synthesis of (D)- And (L)-forms of differentially protected 2-piperidinemethanamine
Perumattam, John,Shearer, Barry G.,Confer, William L.,Mathew, Rose M.
, p. 7183 - 7186 (2007/10/02)
(D)- and (L)-isomers of pipecolic acid were converted into (D)- and (L)-2-piperidinemethanamine using an efficient sequence. The amino groups were selectively protected for further functionalization.
