141774-20-1 Usage
Uses
Used in Pharmaceutical Industry:
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride is used as a selective protein kinase C (PKC) inhibitor for the development of therapeutic agents targeting immune response, cell growth, and memory-related disorders. Its specific interaction with the C1 domain of PKC makes it a valuable tool for assessing the role of PKC in various signaling pathways and for developing targeted treatments.
Used in Research Applications:
In the field of biological research, (S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride serves as an important research tool. It is utilized to study the effects of PKC inhibition on cellular processes and to investigate the potential of (S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride in modulating specific signaling pathways. Its cell permeable and in vivo active properties make it suitable for a wide range of experimental applications.
Used in Drug Development:
The compound is also used in the development of novel drug delivery systems to enhance its bioavailability and therapeutic outcomes. Researchers are exploring the use of various organic and metallic nanoparticles as carriers for (S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide hydrate dihydrochloride, aiming to improve its delivery and efficacy in treating specific conditions related to PKC dysregulation.
References
References/Citations
1) Sullivan et al. (1992), 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain; Mol. Pharmacol., 41 38
2) Sullivan et al. (1991), 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C; Agents Actions 34 142
3) Sullivan et al. (1991), NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs; FEBS Lett., 285 120
4) Miyoshi et al. (2007), mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption; Eur. J. Pharmacol., 562 208
Check Digit Verification of cas no
The CAS Registry Mumber 141774-20-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,7,7 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 141774-20:
(8*1)+(7*4)+(6*1)+(5*7)+(4*7)+(3*4)+(2*2)+(1*0)=121
121 % 10 = 1
So 141774-20-1 is a valid CAS Registry Number.
141774-20-1Relevant articles and documents
Synthesis of (D)- And (L)-forms of differentially protected 2-piperidinemethanamine
Perumattam, John,Shearer, Barry G.,Confer, William L.,Mathew, Rose M.
, p. 7183 - 7186 (2007/10/02)
(D)- and (L)-isomers of pipecolic acid were converted into (D)- and (L)-2-piperidinemethanamine using an efficient sequence. The amino groups were selectively protected for further functionalization.
