14178-13-3

Basic information

• Product Name: 5-ethylpicolinonitrile
• Synonyms: 5-ethylpicolinonitrile
• CAS NO: 14178-13-3
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16252
• Mol File: 14178-13-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-ethylpicolinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ethylpicolinonitrile(14178-13-3)
• EPA Substance Registry System: 5-ethylpicolinonitrile(14178-13-3)

Safety Data

• Hazardous Substances Data: 14178-13-3(Hazardous Substances Data)

Upstream product

• 13509-17-6 5-ethyl-pyridine-2-carboxylic acid amide 
• 14906-62-8 3-ethylpyridine N-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 104-90-5 5-ethyl-2-methyl-pyridine 
• 25186-12-3 2-ethyl-2-propenal-N,N-dimethylhydrazone 
• 920-37-6 2-Chloroacrylonitrile 
• 21913-84-8 5-ethyl-pyridine-2-carboxaldehyde 
• 13509-15-4 5-Ethylpyridin-2-carbonsaeureethylester 
• 770-08-1 5-ethylpyridine-2-carboxylic acid 
• 25186-12-3 1-dimethylamino-1-aza-3-ethyl-1,3-butadiene 
• 110260-91-8 2-cyano-1,4-dihydro-1-dimethylamino-5-ethylpyridine 
• 10177-28-3 5-ethyl-pyridine-2-carbaldehyde oxime 

Relevant articles and documents

Propylphosphonic anhydride (T3P): A remarkably efficient reagent for the one-pot transformation of aromatic, heteroaromatic, and aliphatic aldehydes to nitriles

Propylphosphonic anhydride has been demonstrated to be an efficient reagent for the transformation of aromatic, heteroaromatic, and aliphatic aldehydes to respective nitriles in excellent yields. This procedure offers simple and one-pot access to nitriles and highlights the synthetic utility of T3P as a versatile reagent in organic chemistry. Georg Thieme Verlag Stuttgart - New York.

Process for the preparation of 2-pyridinecarboxylic acid derivatives and 1-amino-1,4-dihydropyridine-2-carboxylic acid derivatives

The process of the invention relates to the reaction of hydrazones of formula II STR1 with α-chloro- or α-bromoarylonitrile or α-chloro- or α-bromoacrylates of formula III STR2 to 1-amino-2-cyano-1,4-dihydropyridines or 1-amino-1,4-dihydropyridine-2-carboxylic acid esters of formula IV STR3 which are converted into pyridine derivatives of formula I STR4 by treatment with an acid, with removal of R4 R5 NH. Y is --CN or --COOR3 and R1 to R5 may be alkyl.

Site-Selectivity in the Cyanation of 3-Substituted Pyridine 1-Oxides with Trimethylsilanecarbonitrile

The cyanation of 3-halo-, 3-methoxy-, and 3-dimethylaminopyridine 1-oxide with trimethylsilanecarbonitrile gave predominantly the corresponding 3-substituted 2-pyridinecarbonitriles.The deoxygenation of nitropyridine 1-oxides to nitropyridines with the same reagent is also described.Keywords - site-selective reaction; trimethylsilanecarbonitrile; pyridine 1-oxide; 2-pyridine-carbonitrile; nitropyridine 1-oxide; deoxygenation; aromatic amine N-oxide; cyanation