14178-69-9Relevant academic research and scientific papers
Tandem addition/cyclization for synthesis of 2-aroyl benzofurans and 2-aroyl indoles by carbopalladation of nitriles
Gong, Julin,Hu, Kun,Shao, Yinlin,Li, Renhao,Zhang, Yetong,Hu, Maolin,Chen, Jiuxi
, p. 488 - 494 (2020/02/03)
The first example of the palladium-catalyzed tandem addition/cyclization of 2-(2-acylphenoxy)acetonitriles with arylboronic acids has been developed, providing a new strategy for the synthesis of 2-aroyl benzofurans with excellent chemoselectivity and wid
Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives
Xu, Wengang,Li, Qingcui,Cao, Chuanpeng,Zhang, Fanglin,Zheng, Hua
, p. 6158 - 6161 (2015/06/08)
A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp2)-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.
Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles
Pautus, Stephane,Yee, Sook Wah,Jayne, Martyn,Coogan, Michael P.,Simons, Claire
, p. 3643 - 3653 (2007/10/03)
Methodology previously described by our group was applied to the preparation of a series of 4-alkyl/aryl-substituted 1-[benzofuran-2-yl-phenylmethyl]-1H-triazoles. The [1,2,4]-triazole derivatives were prepared for a range of alkyl and aryl substituents,
