30095-47-7

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE is used as a reagent for the synthesis of various pharmaceuticals, including anti-inflammatory and analgesic medications. Its unique chemical structure allows for the creation of a diverse range of drug compounds, contributing to the development of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE serves as an intermediate for the production of other organic compounds. Its versatility in chemical reactions makes it a valuable component in the synthesis of a wide array of organic molecules, expanding the scope of chemical research and development.
Used in Research and Development:
2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE is extensively employed in research and development processes within the pharmaceutical and chemical industries. Its application in these processes aids in the discovery and innovation of new compounds and materials, driving advancements in scientific knowledge and technological applications.

InChI:InChI=1/C12H15BrO/c1-12(2,3)10-6-4-9(5-7-10)11(14)8-13/h4-7H,8H2,1-3H3

Upstream product

• 943-27-1 4'-t-butylacetophenone 
• 1746-23-2 4-tert-Butylstyrene 
• 1159013-48-5 2-bromo-1-(4-(tert-butyl)phenyl)ethan-1-ol 
• 101325-12-6 1-(4-tert-butylphenyl)ethanol 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 936078-06-7 2,2‐dibromo‐1‐(4‐tert‐butylphenyl)ethan‐1‐one 
• 22118-09-8 2-bromoacetyl chloride 
• 253185-03-4 tert-butylbenzene 
• 7364-19-4 4-ethyl-tert-butylbenzene 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 186581-53-3 diazomethane 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 772-38-3 4-tert-Butylphenylacetylene 
• 1085526-67-5 (4-tert-butylphenyl)ethynyl bromide 

Downstream Products

• 6321-03-5 1-(4-tert-butyl-phenacyl)-6-chloro-quinolinium; bromide 
• 6321-04-6 1-(4-tert-butyl-phenacyl)-1-methyl-1,2,3,4-tetrahydro-quinolinium; bromide 
• 180901-27-3 2-(4'-t-butylphenyl)-6-chloroimidazo<1,2-b>pyridazine 
• 81539-65-3 4-(4-tert-Butyl-phenyl)-N¹-[1-phenyl-meth-(Z)-ylidene]-imidazole-1,2-diamine 
• 156897-26-6 6-(4-tert-Butyl-phenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine 
• 161139-73-7 1-(4-tert-Butyl-phenyl)-2-(3,5-dimethoxy-phenylamino)-ethanone 
• 3488-46-8 1-[4-(tert-butyl)phenyl]-2-diazoethanone 
• 180901-18-2 2-(4-tert-Butyl-phenyl)-6-phenoxy-imidazo[1,2-b]pyridazine 
• 156146-58-6 2-(4-tert-Butyl-phenyl)-6-fluoro-imidazo[1,2-b]pyridazine 
• 188692-49-1 2-(4-tert-Butyl-phenyl)-6-iodo-imidazo[1,2-b]pyridazine 
• 183667-89-2 6-(4-tert-Butyl-phenyl)-imidazo[2,1-b]thiazole 
• 14178-69-9 benzofuran-2-yl-(4-tert-butyl-phenyl)-methanone 

Relevant academic research and scientific papers

PREPARATION OF PYRAZOLO[3,4-B]PYRIDINES AS ANTIMALARIALS

The present invention relates to pyrazolo[3,4-b]pyridine compounds. The present invention further relates to methods for inhibiting Plasmodium comprising contacting Plasmodium with pyrazolo[3,4-b]pyridine compounds described herein. Also described herein are methods of treating malaria comprising administering pyrazolo[3,4-b]pyridine compounds to a subject in need thereof.

Nucleus-independent chemical shift (NICS) as a criterion for the design of new antifungal benzofuranones

The assertion made by Wu et al. that aromaticity may have considerable implications for molecular design motivated us to use nucleus-independent chemical shifts (NICS) as an aromaticity criterion to evaluate the antifungal activity of two series of indol-4-ones. A linear regression analysis of NICS and antifungal activity showed that both tested variables were significantly related (p –1 for Candida glabrata, Candida krusei and Candida guilliermondii with compounds 15-32, 15-15 and 15-1. The MIC for filamentous fungi was 1.95 μg·mL–1 for Aspergillus niger for compounds 15-1, 15-33 and 15-34. The results obtained support the use of NICS in the molecular design of compounds with antifungal activity.

Synthesis of 1,2-Dicyano-3-arylcycl[3.2.2]azines – First 1,2-Dicarbonitriles Based on Cyclazine Heterocycle

The first 1,2-dicarbonitriles have been prepared for cyclazine systems. In particular, a synthetic procedure to 1,2-dicyano-3-arylcycl[3.2.2]azines has been developed. Unexpected chlorination of 3-arylcycl[3.2.2]azine-1,2-dicarboxylic acid derivatives by thionyl chloride at 4-position was found, which according to theoretical considerations can proceed by the electrophilic (SEAr) mechanism. The compounds are blue fluorophores in 450–480 nm region with quantum yields in toluene of ca. 30 % for non-chlorinated derivatives, which decrease to 3–4 % for chlorinated ones.

Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4- b]pyridines

Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4-b]pyridines targeting Plasmodium falciparum, the deadliest species of the malaria parasite. Hit compounds in this series display sub-micromolar in vitro activity against the intraerythrocytic stage of the parasite as well as little to no toxicity against the human fibroblast BJ and liver HepG2 cell lines. In addition, our hit compounds show good activity against the liver stage of the parasite but little activity against the gametocyte stage. Parasitological profiles, including rate of killing, docking, and molecular dynamics studies, suggest that our compounds may target the Qo binding site of cytochrome bc1.

Selective Debromination of α,α,α-Tribromomethylketones with HBr–H2O Reductive Catalytic System

A debromination of α,α,α-tribromomethylketones is developed for chemoselective synthesis of α-mono- and α,α-dibromomethylketones with high selectivity under H2O–HBr reductive conditions. This method offers an efficient and direct way to synthesize α-mono or α,α-dibromomethylketone compounds in high to excellent yields through the process of HBr self-circulation in water.

Microwave synthesis of 1-aryl-1H-pyrazole-5-amines

A microwave-mediated synthesis of 1H-pyrazole-5-amines utilizing 1 M HCl at 150 °C was developed in order to provide products in a matter of minutes with minimal purification. Most reactions are complete in only 10 min and can be isolated via a simple filtration without the need for further purification by column chromatography or recrystallization. This method tolerates a range of functional groups and can be performed on milligram to gram scales.

Synthesis and Evaluation of 2-Azetidinone and 1H-Pyrrole-2,5-dione Derivatives as Cholesterol Absorption Inhibitors for Reducing Inflammation Response and Oxidative Stress

Excess lipid accumulation can initiate the development and progression of atherosclerotic lesions, thus eventually leading to cardiovascular disease. Lipid-lowering medication therapy is one of the cornerstones of cardiovascular disease therapy. On the basis of the cholesterol absorption inhibitor ezetimibe, we successfully synthesized seven 2-azetidinone derivatives and eighteen 1H-pyrrole-2,5-dione derivatives. Most of the new compounds significantly inhibited cholesterol uptake in vitro. In addition, one of the most active inhibitors, 3-(4-fluorophenyl)-1-[(3S)-3-hydroxy-3-(4-hydroxyphenyl)propyl]-4-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione (14q), showed no cytotoxicity in L02 and HEK293T cell lines. Further evaluation indicated that 14q inhibited considerably the amount of TNF-α, ROS, MDA, and LDH in vitro. Therefore, 14q might be a novel cholesterol absorption inhibitor.

Diaryl-containing imidazole compound and preparation method and medical application thereof

The invention discloses a diaryl-containing imidazole compound. The invention further discloses application of the diaryl-containing imidazole compound to preparation of drugs for preventing or treating Alzheimer's disease. The inventor screens butyrylcholine esterase and IDO1 as carriers for inhibiting the activity to evaluate the effect of the diaryl imidazole compound to treat Alzheimer's disease, and finds that the diaryl imidazole compound has good in vitro activity, and can be further developed as a precursor substance for performing the Alzheimer's disease resistant effect by inhibitingthe activity of cholinesterase. (The formula is shown in the description).

Organocatalytic Enantioselective Selenosulfonylation of a C-C Double Bond to Form Two Stereogenic Centers in an Aqueous Medium

Organocatalytic selenosulfonylation of the C-C double bond of α,β-unsaturated ketones to construct two contiguous stereogenic centers in an aqueous medium was described. A series of α-selenyl and β-sulfonyl ketones with various functional groups were synthesized in good yields and enantioselectivities with saturated NaCl solution as the solvent. In addition, this protocol had been successfully scaled up to a decagram scale via a simple workup procedure.

2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas

Treatment of alkylarenes with N-bromosuccinimide in a mixture of ethyl acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of diethyl carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino- 4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, respectively, in one pot. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions.