30095-47-7

Basic information

• Product Name: 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE
• Synonyms: 2-Bromo-4'-tert-butylacetophenone;2-BroMo-1-[4-(1,1-diMethylethyl)phenyl]ethanone;4-(2-BroMoacetyl)-tert-butylbenzene;p-tert-Butyl α-broMoacetophenone;p-tert-Butyl-ω-broMoacetophenone
• CAS NO: 30095-47-7
• Molecular Formula: C₁₂H₁₅BrO
• Molecular Weight: 255.16
• Product Categories: Aromatics
• Mol File: 30095-47-7.mol
• Article Data: 46

Chemical Properties

• Boiling Point: 305.8°Cat760mmHg
• Flash Point: 36.7°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.000805mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE(30095-47-7)
• EPA Substance Registry System: 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE(30095-47-7)

Safety Data

• Hazardous Substances Data: 30095-47-7(Hazardous Substances Data)

Usage

General Description

2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE, also known as 4-tert-Butylphenacylbromide, is a chemical compound with the molecular formula C12H15BrO. It is an organic compound and a derivative of acetophenone, with a bromine atom attached to the alpha carbon. 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE is commonly used in organic synthesis as a reagent for the synthesis of various pharmaceuticals and organic compounds. It is utilized in the production of various drugs such as anti-inflammatory and analgesic medications. Additionally, it is used as an intermediate in the synthesis of other organic compounds and is widely employed in research and development processes in the pharmaceutical and chemical industries.

InChI:InChI=1/C12H15BrO/c1-12(2,3)10-6-4-9(5-7-10)11(14)8-13/h4-7H,8H2,1-3H3

Upstream product

• 943-27-1 4'-t-butylacetophenone 
• 1746-23-2 4-tert-Butylstyrene 
• 1159013-48-5 2-bromo-1-(4-(tert-butyl)phenyl)ethan-1-ol 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 7364-19-4 4-ethyl-tert-butylbenzene 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 186581-53-3 diazomethane 
• 22118-09-8 2-bromoacetyl chloride 
• 253185-03-4 tert-butylbenzene 
• 936078-06-7 2,2‐dibromo‐1‐(4‐tert‐butylphenyl)ethan‐1‐one 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 101325-12-6 1-(4-tert-butylphenyl)ethanol 
• 772-38-3 4-tert-Butylphenylacetylene 
• 1085526-67-5 (4-tert-butylphenyl)ethynyl bromide 

Downstream Products

• 6321-04-6 1-(4-tert-butyl-phenacyl)-1-methyl-1,2,3,4-tetrahydro-quinolinium; bromide 
• 180901-27-3 2-(4'-t-butylphenyl)-6-chloroimidazo<1,2-b>pyridazine 
• 180900-93-0 2-(4-tert-Butyl-phenyl)-6-phenylsulfanyl-imidazo[1,2-b]pyridazine 
• 188692-68-4 2-(4-tert-Butyl-phenyl)-6-iodo-imidazo[1,2-a]pyridine 
• 188692-49-1 2-(4-tert-Butyl-phenyl)-6-iodo-imidazo[1,2-b]pyridazine 
• 183667-89-2 6-(4-tert-Butyl-phenyl)-imidazo[2,1-b]thiazole 
• 14178-69-9 benzofuran-2-yl-(4-tert-butyl-phenyl)-methanone 
• 914090-82-7 2-azido-1-(4-(tert-butyl)phenyl)ethan-1-one 
• 1359983-60-0 C₁₃H₁₇N₃*ClH 
• 1359983-82-6 C₁₈H₂₅N₃O₂ 
• 70356-09-1 1-(4-methoxyphenyl)-3-(4-tert-butylphenyl)propane-1,3-dione 
• 56108-12-4 4-tert-butylbenzamide 

Relevant articles and documents

PREPARATION OF PYRAZOLO[3,4-B]PYRIDINES AS ANTIMALARIALS

The present invention relates to pyrazolo[3,4-b]pyridine compounds. The present invention further relates to methods for inhibiting Plasmodium comprising contacting Plasmodium with pyrazolo[3,4-b]pyridine compounds described herein. Also described herein are methods of treating malaria comprising administering pyrazolo[3,4-b]pyridine compounds to a subject in need thereof.

Synthesis of 1,2-Dicyano-3-arylcycl[3.2.2]azines – First 1,2-Dicarbonitriles Based on Cyclazine Heterocycle

The first 1,2-dicarbonitriles have been prepared for cyclazine systems. In particular, a synthetic procedure to 1,2-dicyano-3-arylcycl[3.2.2]azines has been developed. Unexpected chlorination of 3-arylcycl[3.2.2]azine-1,2-dicarboxylic acid derivatives by thionyl chloride at 4-position was found, which according to theoretical considerations can proceed by the electrophilic (SEAr) mechanism. The compounds are blue fluorophores in 450–480 nm region with quantum yields in toluene of ca. 30 % for non-chlorinated derivatives, which decrease to 3–4 % for chlorinated ones.

Selective Debromination of α,α,α-Tribromomethylketones with HBr–H2O Reductive Catalytic System

A debromination of α,α,α-tribromomethylketones is developed for chemoselective synthesis of α-mono- and α,α-dibromomethylketones with high selectivity under H2O–HBr reductive conditions. This method offers an efficient and direct way to synthesize α-mono or α,α-dibromomethylketone compounds in high to excellent yields through the process of HBr self-circulation in water.