1417863-33-2Relevant academic research and scientific papers
Synthesis of highly substituted n-hydroxy piperidine via intramolecular reductive cyclization of 1-keto-5-ketoxime
Nagaraj, Muthupandi,Boominathan, Muthusamy,Manikannan, Ramaiyan,Muthusubramanian, Shanmugam,Bhuvanesh, Nattamai
, p. 930 - 940 (2013)
Diasteroselective synthesis of highly substituted N-hydroxypiperidine was achieved by an intramolecular reductive cyclization of monoxime (2) of the 1,5-diketone (1), generated from 2-(cyclohexylthio)-1-phenylethanone and arylaldehyde, using NaBH3 CN. The major product N-hydroxypiperidine (3) has been found to be racemate of a single diastereomer.
