1417907-93-7Relevant academic research and scientific papers
In situ generation of dihydropyridine for the enantioselective transfer hydrogenation of 1,4-benzoxazines
Aillerie, Alexandre,Gosset, Cyrille,Dumont, Clément,Skrzypczak, Valentin,Champetter, Philippe,Pellegrini, Sylvain,Bousquet, Till,Pélinski, Lydie
, p. 54185 - 54188 (2016/07/06)
A new strategy for the enantioselective transfer hydrogenation of benzoxazines involving an in situ generation of Hantzsch ester has been developed. Dihydroadducts were isolated in good yields (75-99%) and enantioselectivities (89-96% ee).
An organocatalyst bearing stereogenic carbon and sulfur centers as an efficient promoter for enantioselective hydrosilylation of 1,4-benzooxazines
Liu, Xiang-Wei,Wang, Chao,Yan, Yan,Wang, Yong-Qiang,Sun, Jian
, p. 6276 - 6280 (2013/07/26)
The efficient and enantioselective hydrosilylation of 3-aryl-1,4- benzooxazines was achieved using an l-phenyl alanine derived new Lewis base catalyst bearing stereogenic carbon and sulfur centers. In the presence of 2 mol % of catalyst, a broad range of 3-aryl-1,4-benzooxazines were hydrosilylated to afford the corresponding chiral 3-aryl-3,4-dihydro-2H-1,4-benzooxazine products with good to high yields (66-98%) and enantioselectivities (70-99% ee). This method provides an alternative approach with great practical application potential to access chiral 3-aryl-3,4-dihydro-2H-1,4-benzooxazines.
