1417985-84-2Relevant academic research and scientific papers
Substituent effects on the phenol coupling reaction catalyzed by the vancomycin biosynthetic P450 enzyme OxyB
Schmartz, Patrick C.,W?lfel, Katharina,Zerbe, Katja,Gad, Emad,El-Tamany, El Sayed,Ibrahim, Hassen K.,Abou-Hadeed, Khaled,Robinson, John A.
supporting information, p. 11468 - 11472 (2013/01/15)
Oxidative phenol coupling reactions are required to establish the cross-linked heptapeptide backbone of vancomycin. The first cross-linking reaction, catalyzed by the P450 enzyme OxyB, is dramatically slower when a chlorine substituent is present in the h
