1417997-93-3 Usage
Uses
Used in Pharmaceutical Industry:
(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide is used as a HDAC8 inhibitor for its cytotoxic effects on lung cancer cells. It targets HDAC8 specifically, making it a potential therapeutic agent for the treatment of lung cancer.
Used in Cancer Research:
In the field of cancer research, (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide is used as a tool to study the role of HDAC8 in the development and progression of lung cancer. Its selective inhibition of HDAC8 can provide insights into the molecular mechanisms underlying the disease and help identify potential therapeutic targets.
Used in Drug Development:
(E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide serves as a lead compound in the development of novel anticancer drugs. Its high selectivity for HDAC8 and cytotoxic effects on lung cancer cells make it a promising candidate for further optimization and development into a more effective and targeted cancer treatment.
Used in Drug Delivery Systems:
Similar to gallotannin, (E)-N-hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamamide could potentially benefit from novel drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. Utilizing carriers such as organic and metallic nanoparticles could improve the compound's efficacy against cancer cells and overcome any limitations associated with its current formulation.
Check Digit Verification of cas no
The CAS Registry Mumber 1417997-93-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,1,7,9,9 and 7 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1417997-93:
(9*1)+(8*4)+(7*1)+(6*7)+(5*9)+(4*9)+(3*7)+(2*9)+(1*3)=213
213 % 10 = 3
So 1417997-93-3 is a valid CAS Registry Number.
1417997-93-3Relevant academic research and scientific papers
HDAC8 INHIBITORS FOR TREATING CANCER
-
Paragraph 0277; 0295, (2015/03/13)
Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.
Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors
Huang, Wei-Jan,Wang, Yi-Ching,Chao, Shi-Wei,Yang, Chen-Yui,Chen, Liang-Chieh,Lin, Mei-Hsiang,Hou, Wen-Chi,Chen, Mei-Yu,Lee, Tai-Lin,Yang, Ping,Chang, Chung-I
, p. 1815 - 1824 (2012/10/29)
Histone deacetylases (HDACs) are a family of enzymes that play a crucial role in biological process and diseases. In contrast to other isozymes, HDAC8 is uniquely incapable of histone acetylation. In order to delineate its physiological function, we devel
