672931-65-6Relevant academic research and scientific papers
An efficient route from coumarins to highly functionalized N-phenyl-2-quinolinones via Buchwald-Hartwig amination
Ullrich, Thomas,Giraud, Francis
, p. 4207 - 4211 (2003)
Multiple substituted N-phenyl-2-quinolinones were obtained in a convenient four-step route from a variety of commercially available coumarins, utilizing customised Buchwald-Hartwig amination protocols for the key reaction. Whereas simple aminolysis of cou
Synthesis and Biological Evaluation of ortho-Aryl N-Hydroxycinnamides as Potent Histone Deacetylase (HDAC) 8 Isoform-Selective Inhibitors
Huang, Wei-Jan,Wang, Yi-Ching,Chao, Shi-Wei,Yang, Chen-Yui,Chen, Liang-Chieh,Lin, Mei-Hsiang,Hou, Wen-Chi,Chen, Mei-Yu,Lee, Tai-Lin,Yang, Ping,Chang, Chung-I
, p. 1815 - 1824 (2012/10/29)
Histone deacetylases (HDACs) are a family of enzymes that play a crucial role in biological process and diseases. In contrast to other isozymes, HDAC8 is uniquely incapable of histone acetylation. In order to delineate its physiological function, we devel
