1418005-59-0Relevant academic research and scientific papers
Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents
He, Shipeng,Dong, Guoqiang,Wu, Shanchao,Fang, Kun,Miao, Zhenyuan,Wang, Wei,Sheng, Chunquan
, p. 7245 - 7260 (2018)
p53-Murine double minute 2 (MDM2) interaction and histone deacetylases (HDACs) are important targets in antitumor drug development. Inspired by the synergistic effects between MDM2 and HDACs, the first MDM2/HDACs dual inhibitors were identified, which sho
A practical synthesis of a cis -4,5-Bis(4-chlorophenyl)imidazoline Intermediate for Nutlin analogues
Shu, Lianhe,Wang, Ping,Liu, Wen,Gu, Chen
, p. 1866 - 1869 (2013/01/15)
A practical synthesis of cis-4,5-bis(4-chlorophenyl)imidazoline, a key intermediate for Nutlin analogues, is reported. The title compound was prepared in 81-88% yield by boric acid catalyzed direct condensation of meso-bis(4-chlorophenyl)ethane-1,2-diamine with a benzoic acid. The process was successfully scaled up in a pilot plant, resulting in >15 kg of the product.
