14181-26-1Relevant academic research and scientific papers
Preparation method of pyrazole-4-aryl derivative
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Paragraph 0019, (2019/01/07)
The invention discloses a preparation method of a pyrazole-4-aryl derivative. The preparation method comprises the following step: mixing an aryl halide derivative, a pyrazole-4-boronic acid pinacol ester derivative, first alkali, a first phase transfer catalyst and a first palladium-based catalyst in a first solvent to carry out reaction so as to prepare the pyrazole-4-aryl derivative. Through the manner, the pyrazole-4-aryl derivative is prepared through the adoption of a one-pot method; the reaction condition is mild and the post-treatment is simple and convenient, so that the method is suitable for multiple aryl halide derivatives, strong in operability and suitable for industrial production; and the obtained pyrazole compound can be widely applied to the field of chemical engineering,medicines, biology and materials.
Efficient and chromatography-free methodology for the modular synthesis of oligo-(1H-pyrazol-4-yl)-arenes with controllable size, shape and steric bulk
Kershaw Cook, Laurence J.,Kearsey, Rachel,Lamb, Jessica V.,Pace, Edward J.,Gould, Jamie A.
, p. 895 - 898 (2016/02/05)
A novel methodology to synthesise oligo-(1H-pyrazol-4-yl)-arenes with controllable size, shape and steric bulk from 1-trityl-1H-pyrazol-4-ylboronate pinacol esters. This straightforward and efficient procedure can be applied to a variety of brominated aro
