1418136-98-7Relevant academic research and scientific papers
Heck alkynylation (copper-free sonogashira coupling) of aryl and heteroaryl chlorides, using Pd complexes of t -Bu2(p -NMe2C 6H4)P: Understanding the structure-activity relationships and copper effects
Pu, Xiaotao,Li, Hongbo,Colacot, Thomas J.
, p. 568 - 581 (2013/03/13)
L2Pd(0) and L2Pd(II) complexes, where L= t-Bu 2(p-NMe2C6H4)P, have been identified as efficient catalyst systems for the Heck alkynylation of a variety of aryl bromides (17 examples) and aryl/heteroaryl chlorides (31 examples) with a range of aryl- and alkyl-acetylenes in excellent yields, under relatively low Pd loadings. The single-crystal X-ray structure determination of the presumably active catalytic species, L2Pd(0), was carried out in this study to better understand the superior activity of the current catalyst system from a structure-activity relationship point of view. The P-Pd-P bond angle indicates that the complex is bent (174.7) in comparison to the perfectly linear (180.0) structure of the analogous Pd(t-Bu3P)2. Preliminary mechanistic studies on the negative copper effect and substrate effect of aryl acetylenes were conducted to better understand the cross-coupling pathway of Heck alkynylation.
