141815-17-0

Usage

Uses

Used in Scientific Research:
C-(4-ALLYL-MORPHOLIN-2-YL)-METHYLAMINE DIHYDROCHLORIDE is used as a chemical compound for various scientific research applications. Its unique structure with a morpholine ring, allyl group, and methylamine may offer potential uses in the synthesis of new compounds or as a reagent in chemical reactions. The dihydrochloride salt form may also be relevant for certain research purposes, such as enhancing solubility or stability in specific conditions. Due to the limited information available, its exact applications in scientific research are not well-defined and may require further investigation.

Upstream product

• 112913-95-8 2-(N-acetylaminomethyl)morpholine 
• 112913-96-9 2-(N-acetylaminomethyl)-4-benzylmorpholine 

Downstream Products

• 141814-74-6 N-(4-Allyl-morpholin-2-ylmethyl)-4-amino-5-chloro-2-methoxy-benzamide 

Relevant academic research and scientific papers

Novel benzamides as selective and potent gastrokinetic agents. III. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-methoxy- and 2-ethoxy-N-[(4-substituted 2-morpholinyl)methyl]-benzamides

A series of 4-amino-5-chloro-2-methoxy- and 2-ethoxy-N-[(4-substituted 2-morpholinyl)methyl]benzamides (11-44) were prepared and evaluated for gastrokinetic activity by determining their effects on the gastric emptying of phenol red semisolid meal in rats. The N-4 substituent includes alkyl, phenoxyalkyl, (4-fluorobenzoyl)alkyl, and heteroarylmethyl groups. The benzamide derivatives, having an isopropyl, isoamyl, neopentyl, 3-(4-chlorophenoxy)propyl, or pyridylmethyl group at N-4, showed potent in vivo gastric emptying activity. In particular, 4-amino-5-chloro-2-ethoxy-N-[[4-(3-pyridylmethyl)-2-morpholinyl]methyl ]benzamide (57b) was equipotent to the 4-fluorobenzyl analogue 1b (AS-4370 as its citrate) in the gastrokinetic activity on phenol red semisolid meal in rats and mice, and on resin pellet solid meal in rats. Moreover, compound 57b was free from dopamine D2 receptor antagonistic activity in both in vitro ([3H]spiperone binding) and in vivo (apomorphine-induced emesis in dogs) tests. Structure-activity relationships of compounds with various substituents at N-4 are also discussed.