14182-15-1

Upstream product

• 75-18-3 dimethylsulfide 
• 100-39-0 benzyl bromide 
• 31410-18-1 benzyl-methyl-phenacyl sulfonium ; bromide 

Downstream Products

• 5925-79-1 1-methyl-2-<(methylthio)methyl>benzene 
• 92208-78-1 (2-Methoxyphenyl)(c-2,t-3-diphenylcycloprop-r-1-yl)methanon 
• 92208-78-1 (2,3–diphenylcyclopropyl)(2–methoxyphenyl)methanone 
• 26597-09-1 1r-benzoyl-2c,3t-diphenylcyclopropane 
• 17608-67-2 cis-2,3-diphenyl-1-benzoylcyclopropane 
• 86118-53-8 (4-Methylphenyl)(c-2,t-3-diphenylcycloprop-r-1-yl)methanon 
• 92282-72-9 (4-Methylphenyl)(t-2,t-3-diphenylcycloprop-r-1-yl)methanon 
• 261924-13-4 methyl-(2-methyl-benzyl)-sulfone 
• 66923-39-5 (2,4-dinitro-phenyl)-(2-methyl-benzyl)-sulfide 
• 86118-58-3 (4-Methoxyphenyl)(c-2,t-3-diphenylcycloprop-r-1-yl)methanon 
• 92282-73-0 (2,3–diphenylcyclopropyl)(4–methoxyphenyl)methanone 
• 92208-75-8 (3-Methylphenyl)(c-2,t-3-diphenylcycloprop-r-1-yl)methanon 
• 92208-75-8 (3-Methylphenyl)(t-2,t-3-diphenylcycloprop-r-1-yl)methanon 

Relevant academic research and scientific papers

A Scaffold-Diversity Synthesis of Biologically Intriguing Cyclic Sulfonamides

A “branching–folding” synthetic strategy that affords a range of diverse cyclic benzo-sulfonamide scaffolds is presented. Whereas different annulation reactions on common ketimine substrates build the branching phase of the scaffold synthesis, a common hydrogenative ring-expansion method, facilitated by an increase of the ring-strain during the branching phase, led to sulfonamides bearing medium-sized rings in a folding pathway. Cell painting assay was successfully employed to identify tubulin targeting sulfonamides as novel mitotic inhibitors.

Generation of Diastereomeric Cyclopropanes from Benzylidenesulfuranes and Chalcones

The reaction of the benzylidenesulfuranes 2, available by deprotonation of the benzylsulfonium bromides 1, with chalcones 3, which are substituted in the aroyl part, leads to the stereoisomeric cyclopropanes 4 and 5.The stereochemistry of 4 and 5 is elucidated by spectroscopy.A carbenic mechanism of formation of 4 and 5 is excluded experimentally.