14182-63-9

Basic information

• Product Name: Ethanethione, 2-(4-Methylphenyl)-1-(4-Morpholinyl)-
• Synonyms: Ethanethione, 2-(4-Methylphenyl)-1-(4-Morpholinyl)-;2-(4-methylphenyl)-1-(4-morpholinyl)Ethanethione;2-(4-methylphenyl)-1-morpholin-4-ylethanethione
• CAS NO: 14182-63-9
• Molecular Formula: C₁₃H₁₇NOS
• Molecular Weight: 235.34518
• Mol File: 14182-63-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 365.9°Cat760mmHg
• Flash Point: 175.1°C
• Appearance: /
• Density: 1.149g/cm³
• Vapor Pressure: 1.51E-05mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: Ethanethione, 2-(4-Methylphenyl)-1-(4-Morpholinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanethione, 2-(4-Methylphenyl)-1-(4-Morpholinyl)-(14182-63-9)
• EPA Substance Registry System: Ethanethione, 2-(4-Methylphenyl)-1-(4-Morpholinyl)-(14182-63-9)

Safety Data

• Hazardous Substances Data: 14182-63-9(Hazardous Substances Data)

Usage

General Description

Ethanethione, 2-(4-Methylphenyl)-1-(4-Morpholinyl)-, also known as thiothixene, is a potent antipsychotic medication belonging to the thioxanthene class. It affects the brain's neurotransmitters, particularly dopamine, which helps in managing symptoms of schizophrenia and other psychotic disorders. Thiothixene is available in tablet and capsule forms and is typically prescribed for the treatment of moderate to severe symptoms of psychosis, including hallucinations, delusions, and disorganized thinking. It is important to use this medication only under the guidance of a healthcare professional, as it may cause side effects such as drowsiness, dizziness, and a potential risk for movement disorders. Regular monitoring and dose adjustments may be necessary to ensure the safe and effective use of thiothixene.

InChI:InChI=1/C13H17NOS/c1-11-2-4-12(5-3-11)10-13(16)14-6-8-15-9-7-14/h2-5H,6-10H2,1H3

Upstream product

• 110-91-8 morpholine 
• 122-00-9 para-methylacetophenone 
• 1866-39-3 4-methylcinnamic acid 
• 220102-36-3 1-(4-methylphenyl)-2-morpholino-2-thioxo-1-ethanone 
• 5757-88-0 p-Methylacetophenone N,N-dimethylhydrazone 
• 622-97-9 1-ethenyl-4-methylbenzene 

Downstream Products

• 5866-46-6 4-(4-phenyl-3-p-tolyl-thiophen-2-yl)-morpholine 
• 111509-99-0 2-Cyano-3-(4-methylbenzyl)-3-morpholinoacrylonitrile 
• 99378-51-5 4-[1-(4-Nitro-benzylsulfanyl)-2-p-tolyl-ethylidene]-morpholin-4-ium; bromide 
• 99378-58-2 4-[5-(4-Nitro-phenyl)-3-p-tolyl-thiophen-2-yl]-morpholine 
• 99378-62-8 (Z)-4-Morpholin-4-yl-4-(4-nitro-benzylsulfanyl)-3-p-tolyl-but-3-en-2-one 
• 99378-60-6 4-[5-(4-Nitro-phenyl)-3-p-tolyl-4-trifluoromethyl-thiophen-2-yl]-morpholine 
• 622-47-9 4-tolylacetic acid 
• 1430835-45-2 C₁₈H₁₉NO₄S 
• 664321-61-3 C₂₃H₂₂N₂O₂S 
• 1417706-40-1 C₂₄H₂₅NO₃S 
• 1417706-37-6 C₂₃H₂₃NO₃S 
• 1393898-13-9 4-(4-methylphenyl)-5-(morpholin-4-yl)-3-phenylthiophen-2(3H)-one 
• 220102-36-3 1-(4-methylphenyl)-2-morpholino-2-thioxo-1-ethanone 

Relevant articles and documents

Willgerodt-kindler's microwave-enhanced synthesis of thioamide derivatives

The Willgerodt-Kindler reaction was applied to a series of aromatic aldehydes and ketones. The reactions were performed in a dipolar aprotic solvent (mainly DMF) in the presence of a base catalyst (4-methylmorpholine) and utilized microwave (mw) irradiation. The pulsed mw technique rather than the continuous irradiation was preferred because it limited side reactions and hydrogen sulfide production. While not always superior to the thermal activation of the reaction, the procedure involving repetitive short pulses of microwave irradiation was found to be faster and result in consistently cleaner products. The technique can be easily applied in a fast parallel synthesis process.

The rapid synthesis of thiomorpholides by Willgerodt-Kindler reaction under microwave heating

The Willgerodt-Kindler reaction of several aryl alkyl ketones with sulfur and morpholine under solvent-free conditions was performed in a domestic microwave oven. Good yields were attained within a very short reaction time (between 3.5-6 min.).

Sulfated tungstate: A green catalyst for synthesis of thiomorpholides via Willgerodt-Kindler reaction

Use of sulfated tungstate as an efficient, green and reusable catalyst for preparation of thiomorpholides via Willgerodt-Kindler reaction pathway is presented. The reaction proceeds under solvent free condition. The advantages of this method are high yiel

Rapid and efficient protocol for Willgerodt–Kindler’s thioacetamides catalyzed by sulfated polyborate

Abstract: A simple and efficient method for the synthesis of one-pot, three-component thioacetamides via Willgerodt–Kindler reaction was developed using a sulfated polyborate catalyst. The method described the reaction of ketones, sulfur, and secondary am

Selective reduction of carbonyl groups in the presence of low-valent titanium reagents

The chemoselective reduction of several structurally diverse compounds containing carbonyl groups was achieved in the presence of low-valent titanium reagents. This novel synthetic method provides easy access to highly selective reduction of carbonyl groups, and possesses several advantages including one-step procedure, convenient manipulation, good to excellent yields, and short reaction times.