5757-88-0

Usage

Type of compound

Hydrazine derivative

Structural features

Dimethyl group attached to nitrogen atoms
Ethylidene group attached to nitrogen atoms
4-methylphenyl group attached to the ethylidene group

Applications

Pharmaceutical research
Organic synthesis (building block for various organic molecules)
Potential use as a pesticide or herbicide (still under research and development)

Toxicity

Considered toxic and potentially harmful to human health

Environmental impact

Potentially harmful to the environment

Handling

Must be handled with care and appropriate safety protocols followed

Upstream product

• 57-14-7 N,N-Dimethylhydrazine 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 64252-53-5 4-methylacetophenone hydrazone 
• 122-00-9 para-methylacetophenone 
• 14182-63-9 1-(morpholin-4-yl)-2-(p-tolyl)ethanethione 
• 1198575-39-1 1,6-dimethyl-3,4-diphenyl-isoquinoline 

Relevant academic research and scientific papers

Efficient reductions of dimethylhydrazones using preformed primary amine boranes

A convenient method for the reduction of N,N-dimethylhydrazones using amine borane complexes generated in situ is described. It was found that primary amine borane complexes performed exceedingly well at reducing N,N-dimethylhydrazones in as little as 1.1 equivalents, furnishing the corresponding air-sensitive hydrazine products in excellent yields.

Synthesis of isoquinolines via Rh(III)-catalyzed C-H activation using hydrazone as a new oxidizing directing group

An efficient and mechanistically interesting method for the synthesis of highly substituted isoquinolines by a Rh(III)-catalyzed hydrazone directed ortho C-H bond activation and annulation without an external oxidant is described. This reaction is accomplished via a C-C and C-N bond formation along with N-N bond cleavage.