1418201-73-6

Basic information

• Product Name: 1-(2-bromophenyl)-N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)methanesulfonamide
• Synonyms: 1-(2-bromophenyl)-N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)methanesulfonamide
• CAS NO: 1418201-73-6
• Molecular Weight: 438.32
• Mol File: 1418201-73-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-bromophenyl)-N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromophenyl)-N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)methanesulfonamide(1418201-73-6)
• EPA Substance Registry System: 1-(2-bromophenyl)-N-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)methanesulfonamide(1418201-73-6)

Safety Data

• Hazardous Substances Data: 1418201-73-6(Hazardous Substances Data)

Upstream product

• 1178847-89-6 (2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-methanamine 
• 24974-74-1 (2-bromophenyl)methanesulfonyl chloride 

Downstream Products

• 1418201-74-7 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1,3-dihydrobenzo[c]isothiazole2,2-dioxide 

Relevant articles and documents

Isatin replacements applied to the highly selective, muscarinic M 1 PAM ML137: Continued optimization of an MLPCN probe molecule

This Letter describes the continued optimization of an MLPCN probe molecule (ML137) with a focused effort on the replacement/modification of the isatin moiety present in this highly selective M1 PAM. A diverse range of structures were validated as viable replacements for the isatin, many of which engendered sizeable improvements in their ability to enhance the potency and efficacy of acetylcholine when compared to ML137. Muscarinic receptor subtype selectivity for the M1 receptor was also maintained.