1418216-89-3

Upstream product

• 1418216-87-1 2,3-bis[4-(benzyloxy)phenyl]succinonitrile 
• 838-96-0 2-[4-(benzyloxy)phenyl]acetonitrile 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 2048-10-4 3,4-bis (4-methoxyphenyl)-1H-pyrrole 
• 2234-38-0 3,4-bis(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid 
• 100-39-0 benzyl bromide 
• 1418216-86-0 2,3-bis[4-(benzyloxy)phenyl]acrylonitrile 

Downstream Products

• 1418216-90-6 methyl 3,4-bis(4-(benzyloxy)phenyl)-1H-pyrrole-2-carboxylate 
• 220230-88-6 methyl 3,4-bis(4-benzyloxyphenyl)-1-<2-(4-methoxyphenyl)-2-oxoethyl>pyrrole-2-carboxylate 
• 168010-02-4 methyl 3,4-bis(4-hydroxyphenyl)-1H-pyrrole-2-carboxylate 

Relevant academic research and scientific papers

Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy

7-Hydroxyneolamellarin A (7-OH-Neo A, 1), a natural marine product derived from sponge Dendrilla nigra, was first synthesized with 10% overall yield under the instruction of convergent synthetic strategy. We found that 7-OH-Neo A could attenuate the accum

Total synthesis and application of natural product of 7-hydroxy novel lamellarin A and analogues of natural product of 7-hydroxy novel lamellarin A

The invention belongs to the technical field of pharmaceutical and chemical engineering, and provides total synthesis and application of a natural product of 7-hydroxy novel lamellarin A and analoguesof the natural product of the 7-hydroxy novel lamellarin A. The invention provides the 7-hydroxy novel lamellarin A natural product and the series of analogues of the 7-hydroxy novel lamellarin A natural product. Tested compounds all have medium to good HIF-1 inhibitory activity, and have no market toxicity under the effective inhibition concentration of HIF-1 of the tested compounds, and it is indicated that the compounds have the potential for treating cancers by inhibiting transcription activating of the HIF-1.

Synthesis of non-symmetrical 3,4-diaryl-substituted pyrroles: Implementation for the preparation of lamellarin R

A straightforward method for synthesising symmetrical and non-symmetrical 3,4-diaryl-substituted pyrroles is proposed, consisting of (i) the condensation reaction between phenylacetonitriles and aldehydes to give acrylonitriles, (ii) the conjugate additio

A Paal-Knorr approach to 3,4-diaryl-substituted pyrroles: Facile synthesis of lamellarins O and Q

A very simple, yet efficient synthetic methodology, to obtain 3,4-diaryl-substituted pyrroles is described. The approach is based on the Knoevenagel condensation between arylacetonitriles and substituted aromatic aldehydes, followed by conjugate addition of cyanide to afford succinonitriles in excellent yields. The products thus obtained were subjected to DIBAL-H reduction, followed by cyclization under acidic conditions to produce the corresponding pyrroles in good overall yields. The utility of this protocol is exemplified by the synthesis of the marine alkaloids lamellarins O and Q.