1418228-31-5

Basic information

• Product Name: C₁₂H₁₆N₂O₃
• CAS NO: 1418228-31-5
• Molecular Weight: 236.271
• Mol File: 1418228-31-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₆N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₆N₂O₃(1418228-31-5)
• EPA Substance Registry System: C₁₂H₁₆N₂O₃(1418228-31-5)

Safety Data

• Hazardous Substances Data: 1418228-31-5(Hazardous Substances Data)

Upstream product

• 149242-83-1 C₁₁H₁₁N₃O₃ 
• 1418228-21-3 C₁₁H₁₁NO₃ 
• 74-89-5 methylamine 
• 38489-74-6 trans-2,5-dimethoxycinnamic acid 

Relevant articles and documents

Synthesis of new N-(arylcyclopropyl)acetamides and N-(arylvinyl)acetamides as conformationally-restricted ligands for melatonin receptors

N-(Arylcyclopropyl)acetamides and N-(arylvinyl)acetamides or methyl ureas have been prepared as constrained analogues of melatonin. The affinity of these new compounds for chicken brain melatonin receptors and recombinant human MT1 and MT2 receptors was evaluated using 2-[ 125I]-iodomelatonin as radioligand. Strict ethylenic or cyclopropyl analogues of the commercialized agonist agomelatine (Valdoxan) were equipotent to agomelatine in binding bioassays. However, the ethylenic analogue was more effective than the cyclopropyl one in the melanophore aggregation bioassay, but was still less potent than the disubstituted 2,7-dimethoxy- naphtalenic compounds.