141834-14-2

Basic information

• Product Name: ETHYL (2S)-2-(([4-(BROMOMETHYL)PHENYL]SULFONYL)AMINO)-4-METHYLPENTANOATE
• Synonyms: ETHYL (2S)-2-(([4-(BROMOMETHYL)PHENYL]SULFONYL)AMINO)-4-METHYLPENTANOATE
• CAS NO: 141834-14-2
• Molecular Formula: C₁₅H₂₂BrNO₄S
• Molecular Weight: 392.31
• Mol File: 141834-14-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL (2S)-2-(([4-(BROMOMETHYL)PHENYL]SULFONYL)AMINO)-4-METHYLPENTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL (2S)-2-(([4-(BROMOMETHYL)PHENYL]SULFONYL)AMINO)-4-METHYLPENTANOATE(141834-14-2)
• EPA Substance Registry System: ETHYL (2S)-2-(([4-(BROMOMETHYL)PHENYL]SULFONYL)AMINO)-4-METHYLPENTANOATE(141834-14-2)

Safety Data

• Hazardous Substances Data: 141834-14-2(Hazardous Substances Data)

Upstream product

• 66176-39-4 4-(bromomethyl)benzene-1-sulfonyl chloride 
• 2743-40-0 L-leucine ethyl ester hydrochloride 
• 2743-60-4 L-Leucine ethyl ester 

Downstream Products

• 141834-27-7 N-ethoxycarbonyl-N-4-bromomethylphenylsulphonyl-L-leucine ethyl ester 
• 141834-23-3 N-ethoxycarbonylmethyl-N-4-bromomethylphenylsulphonyl-L-leucine ethyl ester 
• 141834-17-5 N-4-azidomethylphenylsulphonyl-L-leucine ethyl ester 
• 141834-16-4 N-methyl-N-4-bromomethylphenylsulphonyl-L-leucine ethyl ester 

Relevant articles and documents

Heterocyclic sulfonamide derivatives as antagonists of PAF and angiotensin II

Compounds of formula (I), wherein: A represents: a) a --VR6 group wherein v is --C(=O), --C(=O)O--, --CH2 O--, --CH2 OC(=O)--, --C(=S)--, --CH2 OC(=O)NH--, --C(=S)O--, --CH2 S--, --C(=O)NHSO2 --, --SO2 NHC(=O)-- or --CH2 OSiPh2 --; b) a --CH2 NR9 R10 group or a --CONR9 R10 group wherein each of R9 and R10 is independently hydrogen, -alkyl-, -alkenyl-, -alkynyl, -cycloalkyl, -cycloalkenyl, pyridyl (any of which may optionally be substituted) or a group --D as defined above or R9 and R10 together with the nitrogen atom to which they are attached form a nitrogen-containing heterocyclic ring; c) a group Y where Y is a 5- or 6-membered optionally substituted heterocyclic ring containing one or more heteroatoms selected from nitrogen, oxygen and sulphur; or d) a group --CH2 Y or --C(=O)NHY; where Y is as defined above; B represents a 5- or 6-membered heterocyclic ring containing one or more nitrogen atoms in its ring, are antagonists of platelet activating factor (PAF) and/or antagonists of angiotensin II.

Imidazo (4,5-C) pyridine derivatives as PAF antagonists

Compounds of formula I: STR1 wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and B are variables. These compounds are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or disorders mediated by PAF.