141849-62-9

Basic information

• Product Name: 3-Phenylthiomorpholine
• Synonyms: 3-PHENYL THIOMORPHOLINE;3-Phenylthiomorpholine95%;3-PHENYLTHIOMORPHOLINE 95%
• CAS NO: 141849-62-9
• Molecular Formula: C₁₀H₁₃NS
• Molecular Weight: 179.28
• EINECS: 604-604-1
• Product Categories: API intermediates
• Mol File: 141849-62-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 305.1 °C at 760 mmHg
• Flash Point: 138.3 °C
• Appearance: /
• Density: 1.079 g/cm³
• Vapor Pressure: 0.000841mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Phenylthiomorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenylthiomorpholine(141849-62-9)
• EPA Substance Registry System: 3-Phenylthiomorpholine(141849-62-9)

Safety Data

• Hazardous Substances Data: 141849-62-9(Hazardous Substances Data)

Usage

General Description

3-Phenylthiomorpholine is a chemical compound that belongs to the class of organosulfur compounds. It is a heterocyclic compound with a five-membered ring containing a morpholine ring and a phenylthio group. 3-Phenylthiomorpholine is commonly used as a versatile intermediate in organic synthesis and pharmaceutical research. It has been studied for its potential use in the development of various pharmaceuticals, including antifungal and antibacterial agents. Additionally, it has also been investigated for its potential use as a corrosion inhibitor and as a building block in the synthesis of other organic compounds. Overall, 3-Phenylthiomorpholine is a valuable compound with diverse potential applications in various fields.

InChI:InChI=1/C10H13NS/c1-2-4-9(5-3-1)10-8-12-7-6-11-10/h1-5,10-11H,6-8H2/p+1/t10-/m0/s1

Upstream product

• 141850-03-5 3-Oxo-5-phenyl-1,4-thiazane 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 70-11-1 α-bromoacetophenone 
• 52727-47-6 methyl N-1-phenyl-2-iodoethylcarbamate 
• 22536-46-5 2-((2-oxo-2-phenylethyl)thio)acetic acid 
• 100-52-7 benzaldehyde 
• 141850-02-4 Ethyl 5-<(tert-Butoxycarbonyl)amino>-5-phenyl-3-thiapentanoate 
• 141850-01-3 tert-Butyl N-(2-iodo-1-phenylethyl)carbamate 

Downstream Products

• 141849-66-3 N-Methyl-3-phenyl-1,4-thiazane 
• 141849-70-9 N-(Ethoxycarbonyl)-3-phenyl-1,4-thiazane 
• 141849-67-4 N-Methyl-3-phenyl-1,4-thiazane 1-Oxide 
• 141849-65-2 3-Phenyl-1,4-thiazane 1,1-dioxide 
• 141849-73-2 N-(Ethoxycarbonyl)-3-phenyl-1,4-thiazane 1,1-dioxide 
• 141849-77-6 N-(tert-Butoxycarbonyl)-3-phenyl-1,4-thiazane 1,1-dioxide 
• 141849-75-4 N-(tert-Butoxycarbonyl)-3-phenyl-1,4-thiazane 1-Oxide 
• 141849-75-4 N-(tert-Butoxycarbonyl)-3-phenyl-1,4-thiazane 1-Oxide 
• 141849-71-0 N-(Ethoxycarbonyl)-3-phenyl-1,4-thiazane 1-Oxide 
• 141849-71-0 N-(Ethoxycarbonyl)-3-phenyl-1,4-thiazane 1-Oxide 
• 1520-42-9 1,1,2-triphenylethane 
• 1312573-33-3 C₁₈H₁₈ClNOS 

Relevant articles and documents

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines

The increasing diversity of reactions mediated by biocatalysts has led to development of multistep in vitro enzyme cascades, taking advantage of generally compatible reaction conditions. The construction of pathways within single whole cell systems is much less explored, yet has many advantages. Herein we report the generation of a successful whole cell de novo enzyme cascade for the diastereoselective and/or enantioselective conversion of simple, linear keto acids into valuable cyclic amine products. The pathway starts with carboxylic acid reduction that triggers a transamination, imine formation, and subsequent imine reduction. Construction and optimization of the system was achieved by standard genetic manipulation and the cascade required only starting material, amine donor, and whole cell catalyst with cofactors provided internally by glucose metabolism. A panel of synthetic keto acids provided access to piperidines in high conversions (up to 93%) and enantiomeric excess (up to 93%).

Thiomorpholine Derivatives with Hypolipidemic and Antioxidant Activity

A number of thiomorpholine derivatives that are structurally similar to some substituted morpholines possessing antioxidant and hypocholesterolemic activity were synthesized. The new compounds incorporate an antioxidant moiety as the thiomorpholine N-subs

New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents

Amine or amide derivatives bearing the 2,6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2,6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol.