141849-62-9

Usage

Uses

Used in Pharmaceutical Research and Development:
3-Phenylthiomorpholine is used as a key intermediate in the synthesis of various pharmaceuticals, leveraging its unique structural properties to contribute to the development of new drugs with antifungal and antibacterial properties. Its presence in these compounds can enhance their efficacy against a range of pathogens.
Used in Corrosion Inhibition:
3-Phenylthiomorpholine is utilized as a corrosion inhibitor, taking advantage of its chemical properties to protect materials from degradation in various industrial applications. Its ability to form protective layers and reduce the rate of corrosion makes it a valuable component in industrial coatings and other protective formulations.
Used in Organic Synthesis:
As a building block in organic synthesis, 3-Phenylthiomorpholine is employed in the creation of a wide array of organic compounds for different purposes. Its reactivity and structural features make it a preferred choice for chemists looking to construct complex organic molecules with specific functionalities.

InChI:InChI=1/C10H13NS/c1-2-4-9(5-3-1)10-8-12-7-6-11-10/h1-5,10-11H,6-8H2/p+1/t10-/m0/s1

Upstream product

• 156-57-0 2-mercaptoethylamine hydrochloride 
• 70-11-1 α-bromoacetophenone 
• 141850-02-4 Ethyl 5-<(tert-Butoxycarbonyl)amino>-5-phenyl-3-thiapentanoate 
• 141850-03-5 3-Oxo-5-phenyl-1,4-thiazane 
• 22536-46-5 2-((2-oxo-2-phenylethyl)thio)acetic acid 
• 141850-01-3 tert-Butyl N-(2-iodo-1-phenylethyl)carbamate 
• 52727-47-6 methyl N-1-phenyl-2-iodoethylcarbamate 
• 100-52-7 benzaldehyde 

Downstream Products

• 141849-71-0 N-(Ethoxycarbonyl)-3-phenyl-1,4-thiazane 1-Oxide 
• 141849-71-0 N-(Ethoxycarbonyl)-3-phenyl-1,4-thiazane 1-Oxide 
• 141849-75-4 N-(tert-Butoxycarbonyl)-3-phenyl-1,4-thiazane 1-Oxide 
• 141849-75-4 N-(tert-Butoxycarbonyl)-3-phenyl-1,4-thiazane 1-Oxide 
• 141849-77-6 N-(tert-Butoxycarbonyl)-3-phenyl-1,4-thiazane 1,1-dioxide 
• 141849-73-2 N-(Ethoxycarbonyl)-3-phenyl-1,4-thiazane 1,1-dioxide 
• 141849-65-2 3-Phenyl-1,4-thiazane 1,1-dioxide 
• 141849-67-4 N-Methyl-3-phenyl-1,4-thiazane 1-Oxide 
• 141849-70-9 N-(Ethoxycarbonyl)-3-phenyl-1,4-thiazane 
• 141849-66-3 N-Methyl-3-phenyl-1,4-thiazane 
• 1312573-33-3 C₁₈H₁₈ClNOS 
• 1520-42-9 1,1,2-triphenylethane 

Relevant academic research and scientific papers

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines

The increasing diversity of reactions mediated by biocatalysts has led to development of multistep in vitro enzyme cascades, taking advantage of generally compatible reaction conditions. The construction of pathways within single whole cell systems is much less explored, yet has many advantages. Herein we report the generation of a successful whole cell de novo enzyme cascade for the diastereoselective and/or enantioselective conversion of simple, linear keto acids into valuable cyclic amine products. The pathway starts with carboxylic acid reduction that triggers a transamination, imine formation, and subsequent imine reduction. Construction and optimization of the system was achieved by standard genetic manipulation and the cascade required only starting material, amine donor, and whole cell catalyst with cofactors provided internally by glucose metabolism. A panel of synthetic keto acids provided access to piperidines in high conversions (up to 93%) and enantiomeric excess (up to 93%).

Continuous Flow Synthesis of Morpholines and Oxazepanes with Silicon Amine Protocol (SLAP) Reagents and Lewis Acid Facilitated Photoredox Catalysis

Photocatalytic coupling of aldehydes and silicon amine protocol (SLAP) reagents enables the simple, scalable synthesis of substituted morpholines, oxazepanes, thiomorpholines, and thiazepanes under continuous flow conditions. Key to the success of this process is the combination of an inexpensive organic photocatalyst (TPP) and a Lewis acid additive, which form an amine radical cation that is easily reduced to complete the catalytic cycle. Di- and trisubstituted SLAP reagents are formed in one step by an iron-catalyzed aminoetherification of olefins.

Thiomorpholine Derivatives with Hypolipidemic and Antioxidant Activity

A number of thiomorpholine derivatives that are structurally similar to some substituted morpholines possessing antioxidant and hypocholesterolemic activity were synthesized. The new compounds incorporate an antioxidant moiety as the thiomorpholine N-subs

SnAP reagents for the transformation of aldehydes into substituted thiomorpholines - An alternative to cross-coupling with saturated heterocycles

It's a SnAP! The transformation of aldehydes into N-unsubstituted 3-thiomorpholines provides a convenient alternative to metal-catalyzed cross-coupling reactions, which are generally unsuited to the functionalization of saturated N-heterocycles. A copper-mediated radical cyclization is the key to the mild conditions, high functional group tolerance, and broad substrate scope offered by these reagents. Copyright

New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents

Amine or amide derivatives bearing the 2,6-di-tert-butyl phenol moiety are synthesised. Almost all are antioxidants, reduce acute inflammation and inhibit COX-1 and lipoxygenase activity. The most potent anti-inflammatory, COX-1 inhibitor and antioxidant agent, with low toxicity, is 2,6-di-tert-butyl-4-thiomorpholin-4-ylmethyl-phenol.

Synthesis of 2-Phenyl-, 3-Phenyl-, cis-2,3-Diphenyl-, and trans-2,3-Diphenyl-1,4-thiazanes and Derivatives (N-Methyl, N-Alkoxycarbonyl, S-Oxides, and S,S-Dioxides)

The syntheses of the title 1,4-thiazanes (thiamorpholines) by reduction of the 5-oxa-1,4-thiazanes resulting from the lactamization of the appropriate acyclic phenyl derivatives of 5-amino-3-thiapentanoic acid are reported.The oxidation reactions at sulfu