141859-35-0Relevant academic research and scientific papers
Novel 2-thioxanthine and dipyrimidopyridine derivatives: Synthesis and antimicrobial activity
El-Kalyoubi, Samar,Agili, Fatmah,Youssif, Shaker
, p. 19263 - 19276 (2015)
Several fused imidazolopyrimidines were synthesized starting from 6-amino-1- methyl-2-thiouracil (1) followed by nitrosation, reduction and condensation with different aromatic aldehydes to give Schiff's base. The dehydrocyclization of Schiff's bases using iodine/DMF gave Compounds 5a-g. The methylation of 5a-g using a simple alkylating agent as dimethyl sulfate ((CH3)2SO4) gave either monoalkylated imidazolopyrimidine 6a-g at room temperature or dialkylated derivatives 7a-g on heating 6a-g with ((CH3)2SO4). On the other hand, treatment of 1 with different aromatic aldehydes in absolute ethanol in the presence of conc. hydrochloric acid at room temperature and/or reflux with acetic acid afforded bis-5,5′-diuracylmethylene 8a-e, which cyclized on heating with a mixture of acetic acid/HCl (1:1) to give 9a-e. Compounds 9a-e can be obtained directly by refluxing of Compound 1 with a mixture of acetic acid/HCl. The synthesized new compounds were screened for antimicrobial activity, and the MIC was measured.
FACILE AND GENERAL SYNTHESIS OF 8-SUBSTITUTED 2-METHYLTHIOPURIN-6-ONES
Nagamatsu, Tomohisa,Yamasaki, Hiroo
, p. 775 - 790 (2007/10/02)
A variety of 3-methyl-6-oxo-2-thioxo-1,2,3,6-tetrahydropurine (3a) and its 8-substituted derivatives (3b-o) were synthesized by oxidative cyclization of the reaction product of 5,6-diamino-1-methyl-2-thiouracil (1) with an appropriate aldehyde or 6-amino-
