16837-08-4

Usage

Uses

Used in Pharmaceutical Industry:
6-Amino-1-methyl-2-thio-uracil is used as a precursor in the synthesis of various medicinally important compounds, particularly for the development of antiviral agents. Its unique structure and potential biological activities make it a valuable starting material for creating novel pharmaceuticals.
Used in Drug Discovery and Development:
6-Amino-1-methyl-2-thio-uracil is utilized in drug discovery and development due to its potential anti-inflammatory and antioxidant properties. These properties further expand its potential applications in the creation of new therapeutic agents for various medical conditions.
Used in Antiviral Agent Synthesis:
6-Amino-1-methyl-2-thio-uracil is employed as a key component in the synthesis of antiviral agents, where its unique structure and biological activities contribute to the development of effective treatments against viral infections.

InChI:InChI=1/C5H7N3OS/c1-8-3(6)2-4(9)7-5(8)10/h2H,6H2,1H3,(H,7,9,10)

Upstream product

• 598-52-7 1-(methyl)-thiourea 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 100516-75-4 6-amino-1-methyl-1H-pyrimidin-4-one 
• 1124255-54-4 1-methyl-6-(3-methoxyphenyl)-2,5,7,8-tetrahydro-2-thiopyrimido[4,5-d]pyrimidin-4-one 
• 1124255-44-2 1-methyl-6-(4-tolyl)-2,5,7,8-tetrahydro-2-thiopyrimido[4,5-d]pyrimidin-4-one 
• 1124255-48-6 1-methyl-6-(4-methoxyphenyl)-2,5,7,8-tetrahydro-2-thiopyrimido[4,5-d]pyrimidin-4-one 
• 1124255-46-4 1-methyl-6-(4-nitrophenyl)-2,5,7,8-tetrahydro-2-thiopyrimido[4,5-d]pyrimidin-4-one 
• 1124255-41-9 1-methyl-6-phenyl-2,5,7,8-tetrahydro-2-thiopyrimido[4,5-d]pyrimidin-4-one 
• 1124255-56-6 1-methyl-6-(3-chlorophenyl)-2,5,7,8-tetrahydro-2-thiopyrimido[4,5-d]pyrimidin-4-one 
• 1124255-71-5 ethyl 7-amino-1-methyl-4-oxo-5-(4-chlorophenyl)-1,2,3,4-tetrahydro-2-thiopyrido[2,3-d]pyrimidine-6-carboxylate 
• 1124255-68-0 ethyl 7-amino-1-methyl-4-oxo-5-(4-bromophenyl)-1,2,3,4-tetrahydro-2-thiopyrido[2,3-d]pyrimidine-6-carboxylate 
• 1124255-66-8 ethyl 7-amino-1-methyl-4-oxo-5-(4-hydroxyphenyl)-1,2,3,4-tetrahydro-2-thiopyrido[2,3-d]pyrimidine-6-carboxylate 
• 1124255-65-7 ethyl 7-amino-1-methyl-4-oxo-5-phenyl-1,2,3,4-tetrahydro-2-thiopyrido[2,3-d]pyrimidine-6-carboxylate 
• 141859-35-0 6-Amino-5-{[1-(4-fluoro-phenyl)-meth-(E)-ylidene]-amino}-1-methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 141859-27-0 6-Amino-5-{[1-(4-bromo-phenyl)-meth-(E)-ylidene]-amino}-1-methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 141859-26-9 6-Amino-5-{[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amino}-1-methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 

Relevant academic research and scientific papers

Synthesis and evaluation of antitumour activities of novel fused tri-And tetracyclic uracil derivatives

Simple one-pot syntheses of indenopyrrolopyrimidines and indolopyrrolopyrimidines were achieved via the cyclocondensation of 6-Aminouracils and, respectively, ninhydrin and isatin in the presence of catalytic amounts of glacial acetic acid. Similarly, 5,6-diaminouracil derivatives were used as starting materials for the synthesis of indenopteridines and indolopteridines via their reaction with ninhydrin and isatin, respectively. The synthesised compounds were evaluated for antitumour activity against a human hepatocellular carcinoma cell line (HepG2), some showing antitumour activity comparable with 5-fluorouracil and imatinib.