141859-95-2

Upstream product

• 95671-21-9 2,4-dimethyl-2,4-dideoxy-xylitol 
• 135067-27-5 (S)-2-((2R,3R,7S,10R)-7-Isopropyl-3,10-dimethyl-1,5-dioxa-spiro[5.5]undec-2-yl)-propan-1-ol 
• 141859-96-3 (2R,3S,4R)-2,4-dimethyl-5-phenylthio-1,3-pentane diol 
• 141901-97-5 (2S,3R,4S)-2,4-Dimethyl-5-phenylsulfanyl-pentane-1,3-diol 
• 141859-94-1 (2R,3S,7S,10R)-7-Isopropyl-3,10-dimethyl-2-((S)-1-methyl-2-phenylsulfanyl-ethyl)-1,5-dioxa-spiro[5.5]undecane 
• 141859-94-1 (2S,3R,7S,10R)-7-Isopropyl-3,10-dimethyl-2-((R)-1-methyl-2-phenylsulfanyl-ethyl)-1,5-dioxa-spiro[5.5]undecane 
• 135067-25-3 (2S,3R,4R)-2,4-dimethyl-1,3,5-tris(trimethylsiloxy)pentane 
• 40955-11-1 (2S,3S,4R)-3-Hydroxy-2,4-dimethyl-pentanedioic acid dimethyl ester 

Downstream Products

• 141859-93-0 (E)-(4R,5R)-5-Hydroxy-4,6-dimethyl-hept-2-enoic acid 
• 208465-69-4 (R)-((3R,4R,E)-7-((S,2E,4E)-8-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-4-methylocta-2,4-dienylamino)-2,4-dimethyl-7-oxohept-5-en-3-yl) 1-(2-(chloromethyl)-oxazole-4-carbonyl)pyrrolidine-2-carboxylate 
• 208465-71-8 (R)-1-(2-Iodomethyl-oxazole-4-carbonyl)-pyrrolidine-2-carboxylic acid (E)-(1R,2R)-4-[(2E,4E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-8-hydroxy-4-methyl-octa-2,4-dienylcarbamoyl]-1-isopropyl-2-methyl-but-3-enyl ester 
• 208465-70-7 (R)-((3R,4R,E)-7-((S,2E,4E)-6-(tert-butyldiphenylsilyloxy)-8-hydroxy-4-methylocta-2,4-dienylamino)-2,4-dimethyl-7-oxohept-5-en-3-yl) 1-(2-(chloromethyl)oxazole-4-carbonyl)pyrrolidine-2-carboxylate 
• 208465-60-5 (R)-((3R,4R,E)-7-((S,2E,4E)-6-(tert-butyldiphenylsilyloxy)-4-methyl-8-oxoocta-2,4-dienylamino)-2,4-dimethyl-7-oxohept-5-en-3-yl) 1-(2-(iodomethyl)oxazole-4-carbonyl)pyrrolidine-2-carboxylate 
• 208465-73-0 1-((1R,2S)-3-Benzenesulfonyl-1-isopropyl-2-methyl-propoxymethyl)-4-methoxy-benzene 

Relevant academic research and scientific papers

Total synthesis of pristinamycin II(B)

An intramolecular Takai reaction of the iodoaldehyde 4a proceeded with a moderate efficiency to give the macrocyclic hydroxy compound 1b, identified to an authentic sample.

Towards the synthesis of pristinamycin PIIA; preparation of the optically pure C-3/C-7 fragment

The two diastereomeric ketals formed from (-)- menthone and a syn meso triol, 5, have been converted, stereoconvergently, into the title synthon.