141859-96-3

Upstream product

• 141859-94-1 (2S,3R,7S,10R)-7-Isopropyl-3,10-dimethyl-2-((R)-1-methyl-2-phenylsulfanyl-ethyl)-1,5-dioxa-spiro[5.5]undecane 
• 930-69-8 sodium thiophenolate 
• 95671-21-9 2,4-dimethyl-2,4-dideoxy-xylitol 
• 89329-01-1 xylo-3-hydroxy-2,4-dimethyl-glutaric acid 
• 40955-11-1 (2S,3S,4R)-3-Hydroxy-2,4-dimethyl-pentanedioic acid dimethyl ester 
• 135067-25-3 (2S,3R,4R)-2,4-dimethyl-1,3,5-tris(trimethylsiloxy)pentane 
• 135067-27-5 (S)-2-((2R,3R,7S,10R)-7-Isopropyl-3,10-dimethyl-1,5-dioxa-spiro[5.5]undec-2-yl)-propan-1-ol 

Downstream Products

• 141859-95-2 (2S,3R)-1-Benzenesulfonyl-2,4-dimethyl-pentan-3-ol 

Relevant academic research and scientific papers

A convenient preparation of elements of the stereotriade

Enzyme-catalysed acetylation of either syn,syn- or anti,anti-2,4-dimethyl-1,3,5-pentane triol, easily obtained from a mixture of diastereomeric 3-hydroxy-2,4-dimethylglutaric acids, proceeds stereoselectively with preferential attack of the hydromethyl group linked to the R carbon atom of the starting triol, hence providing synthons useful for preparing compounds of the polypropionic pool.

Towards the synthesis of pristinamycin PIIA; preparation of the optically pure C-3/C-7 fragment

The two diastereomeric ketals formed from (-)- menthone and a syn meso triol, 5, have been converted, stereoconvergently, into the title synthon.