1418635-75-2

Upstream product

• 63503-60-6 3-chlorophenylboronic acid 
• 71730-46-6 benzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 1025496-32-5 C₁₂H₁₀BClO₂ 

Relevant academic research and scientific papers

Synthesis and Application of Hexamethyl-1,1′-spirobiindane-Based Phosphine-Oxazoline Ligands in Ni-Catalyzed Asymmetric Arylation of Cyclic Aldimines

With the vastly increasing applications of chiral phosphine-oxazoline (PHOX) hybrid ligands in various transition-metal-catalyzed reactions, novel PHOX ligands bearing innovative backbones are highly valuable and in great demand. This study describes the development of a new type of chiral PHOX ligands based on a hexamethyl-1,1′-spirobiindane scaffold and incorporating both a phosphine and an oxazoline moiety. The optimal ligand provided high yields and excellent enantioselectivities for the Ni-catalyzed asymmetric arylation of cyclic N-sulfonyl imines with arylboronic acids leading to chiral amines.

Phosphine-oxazoline ligand compounds based on tetramethylspirobiindane skeleton as well as preparation method and application of compounds

The invention discloses phosphine-oxazoline ligand compounds based on a tetramethylspirobiindane skeleton as well as a preparation method and application of the compounds. The phosphine-oxazoline ligand compounds are compounds having a structure represent

Preparation method of chiral benzosulfonamide compound

The invention relates to a preparation method of a chiral benzosulfonamide compound. The preparation method particularly includes the steps of: performing an asymmetric addition reaction to an organic boric acid compound represented as the formula (1) and a benzosulfonimide represented as the formula (2) to generate the chiral benzosulfonamide compound represented as the formula (3), wherein the formulas (1), (2) and (3) are described as follows. The preparation method has simple conditions and simple operations, is high in reaction yield and enantio-selectivity, and has excellent application prospect.

Ni(ii)-catalyzed asymmetric addition of arylboronic acids to cyclic imines

A Ni(ii)-catalyzed asymmetric addition of arylboronic acids to cyclic aldimines and ketimines is reported. Our tropos phosphine-oxazoline biphenyl ligand is crucial for the high catalytic activity, which coordinates to Ni(ii) to form a complex with a single axial configuration. The desired chiral amine products could be prepared with excellent yields (up to 99%) and enantioselectivities (up to 99.8%) under mild reaction conditions.

Rhodium-catalyzed highly enantioselective addition of arylboronic acids to cyclic aldimines: Practical asymmetric synthesis of cyclic sulfamidates

A highly efficient asymmetric arylation of cyclic N-sulfonyl aldimines with arylboronic acids catalyzed by a rhodium/ sulfur-olefin ligand complex under mild conditions is described. A wide range 4-aryl-3,4-dihydro-1,2,3- benzoxathiazine 2,2-dioxides were obtained in extremely high yields (93-99%) and high enantiomeric purities (97-99% ee).

Simple branched sulfur-olefins as chiral ligands for Rh-catalyzed asymmetric arylation of cyclic ketimines: Highly enantioselective construction of tetrasubstituted carbon stereocenters

New, simple, sulfinamide-based branched olefin ligands have been developed and successfully used in Rh-catalyzed asymmetric arylations of cyclic ketimines, providing efficient and highly enantioselective access to valuable benzosultams and benzosulfamidat