1418739-12-4

Basic information

• Product Name: C₁₉H₁₆N₂O₅
• Synonyms: C₁₉H₁₆N₂O₅
• CAS NO: 1418739-12-4
• Molecular Weight: 352.346
• Mol File: 1418739-12-4.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₆N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₆N₂O₅(1418739-12-4)
• EPA Substance Registry System: C₁₉H₁₆N₂O₅(1418739-12-4)

Safety Data

• Hazardous Substances Data: 1418739-12-4(Hazardous Substances Data)

Upstream product

• 875318-86-8 2-(2-(6-methoxy-1H-indol-3-yl)ethyl)isoindoline-1,3-dione 
• 7223-50-9 N-propargylphthalimide 
• 1074-82-4 potassium phtalimide 
• 58755-70-7 1-iodo-4-methoxy-2-nitrobenzene 
• 64-18-6 formic acid 
• 96-96-8 4-methoxy-2-nitroaniline 

Relevant articles and documents

Synthetic method of N-((2-(1,3-dioxo-dihydroisoindol-2-yl)-propionyl)-5-methoxy)formamide

The invention discloses a synthetic method of N-(2-(1,3-dioxo-dioxoisoindolin-2-yl)-propionyl)-5-methoxy)formamide. 2-nitro-4-anisidine is taken as an initial raw material, 2-iodine-3-methoxy nitrobenzene is obtained by substitution reaction on a diazonium salt aromatic ring, and then the 2-iodine-3-methoxy nitrobenzene and propargylamine are subjected to Castro-Stephens coupling reaction, reduction reaction and acylation reaction to obtain the N-(2-(1,3-dihydroisoindol-2-yl)-propionyl)-5-methoxy)formamide. Reaction conditions are optimized based on the prior art, and concentrated sulfuric acid replaces concentrated nitric acid; manganese dioxide solid is adopted to catalyze the reaction of propargyl bromide and phthalimide kali salt; manganous-manganic oxide is adopted as a catalyst to catalyze and promote the reaction together with triethylamine, bispalladium chloride and cuprous iodide, the reaction efficiency and yield of a final product are improved, and the industrial production and promotion of the N-(2-(1,3-dioxo-dihydroisoindol-2-yl)-propionyl)-5-methoxy)formamide are facilitated.

Rapid total synthesis of (±)trigonoliimine A via a Strecker/Houben-Hoesch sequence

A novel synthetic route to the hexacyclic system of trigonoliimine A was accomplished in four steps from N-phthaloyl 6-OMe-tryptamine. Key reactions include a three-component Strecker-type reaction to fashion the two C-N bonds in the D ring and a subsequent Houben-Hoesch type cyclization to deliver the characteristic seven-membered C ring.