141874-44-4

Upstream product

• 100-39-0 benzyl bromide 
• 86884-90-4 (S)-2-methylglycidol 
• 97389-48-5 2-((benzyloxy)methyl)-2-methyloxirane 
• 946155-60-8 C₁₈H₂₂O₅S 
• 109240-73-5 (2R)-2-methylpropane-1,2,3-triol monobenzyl ether 

Downstream Products

• 1132810-78-6 (S)-1-benzyloxy-4-(2,5-dimethoxy-3,4,6-trimethylphenyl)-2-methyl-butan-2-ol 
• 120633-62-7 (R)-1-benzyloxy-2-methyl-4-pentene-2-ol 
• 141874-45-5 (R)-1-Benzyloxy-2-methyl-pent-4-yn-2-ol 
• 97389-50-9 [(R)-5-Benzyloxymethyl-5-methyl-dihydro-furan-(2E)-ylidene]-acetic acid methyl ester 

Relevant academic research and scientific papers

Enantiocomplementary chemoenzymatic asymmetric synthesis of (R)- And (S)-chromanemethanol

A non-lipase-based, enantiocomplementary chemoenzymatic route towards enantiopure (R)- and (S)-chromane-methanol (12), which are the key building blocks for the synthesis of stereoisomerically pure α-tocopherols, has been achieved by the biocatalytic reso

Chemoenzymatic approach to enantiomerically pure (R)-3-Hydroxy-3-methyl-4- pentenoic acid ester and its application to a formal total synthesis of taurospongin A

(R)-3-Hydroxy-3-methyl-5-hexanoic acid p-methoxybenzyl ester 1b was prepared by carbonchain elongation on both termini of the starting material, (R)-3-benzyloxy-2-methylpropane-1,2-diol 2a, which was prepared by an over-expressed Bacillus subtilis epoxide hydrolase-catalyzed enantioselective hydrolysis of the racemic 1-benzyloxymethyl-1-methyloxirane 3. One of the key steps of the requisite transformation was the Rhodococcus rhodochrous NBRC 15564-mediated hydrolysis of a cyano group to a carboxyl group under neutral conditions, to exclude any racemization of the intermediate and/or product. The enantiomerically pure form of (R)-1b was applied to a new formal total synthesis of taurospongin A.

Selectivity enhancement of enantio- and stereo-complementary epoxide hydrolases and chemo-enzymatic deracemization of (±)-2-methylglycidyl benzyl ether

The kinetic resolution of (±)-2-methylglycidyl benzyl ether was achieved via enantioselective biohydrolysis using microbial and plant epoxide hydrolases. Depending on the type of enzyme, opposite enantiopreference and stereo-complementary mode of action (

An alternative approach to (S)- and (R)-2-methylglycidol O-benzyl ether derivatives

This report describes the gram scale synthesis of (S)- and (R)-2,2,4-trimethyl-4-(hydroxymethyl)-1,3-dioxolanes using the Sharpless asymmetric dihydroxylation (AD) of the Weinreb amide of 2-methyl-2-propenoic acid. The 2-methylglycerol acetonides resultan

Preparation of C-4 alkylated dideoxyribosides: Potential precursors to a novel series of nucleosides

Methallyl alcohol can be converted in five simple operations (alkylation, epoxidation, alkynyl-coupling, hydroboration/oxidation, cyclization) to C-5 protected, chiral, non-racemic dideoxyribosides containing an alkyl appendage at the C-4 site.