141884-90-4

Upstream product

• 100-52-7 benzaldehyde 
• 542-32-5 (R,S)-2-aminoadipic acid 
• 1118-90-7 L-homoglutamic acid 
• 141884-89-1 Acetic acid 1-benzyl-6-oxo-piperidin-2-ylmethyl ester 
• 141884-80-2 1-Benzyl-6-iodomethyl-piperidin-2-one 
• 127839-87-6 Hex-5-enethioic acid benzylamide 
• 141884-72-2 N-Benzyl-hex-5-enimidothioic acid methyl ester 

Downstream Products

• 1065330-06-4 N-[(2,4-dichlorophenyl)methyl]-6-oxo-1-(phenylmethyl)-2-piperidinecarboxamide 
• 1065330-05-3 N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-6-oxo-1-(phenylmethyl)-2-piperidinecarboxamide 
• 1065330-04-2 N-[(2-chloro-4-fluorophenyl)methyl]-6-oxo-1-(phenylmethyl)-2-piperidinecarboxamide 

Relevant academic research and scientific papers

PIPERIDINONE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: (formula I) The compounds or salts modulate P2X7 receptor function and are capable of interfering with the effects of ATP at the P2X7 receptor. The invention also provides the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease, in particular pain such as inflammatory pain, neuropathic pain or visceral pain.

ELECTROPHILIC OLEFIN HETEROCYCLIZATION IN ORGANIC SYNTHESIS. FORMATION OF δ-LACTAMS BY IODINE-INDUCED LACTAMIZATION OF δ,ε-UNSATURATED THIOIMIDATES

The diastereoselective iodine-induced lactamization of δ,ε-unsaturated thioimidates (1) accessible from allylation of a dianion of N-benzyl-3-phenylsulfonylpropionamide (3) followed by elaboration gave the substituted δ-lactams (2).