141891-32-9Relevant academic research and scientific papers
(E)-(Arylmethyleneaminoxy)acetamides as analogues of neuroleptic benzamides: Synthesis and D2-dopaminergic binding affinity
Macchia,Manera,Martinelli,Orlandini,Romagnoli,Rossello,Chellini
, p. 719 - 724 (2007/10/03)
Some type B (E)-(arylmethyleneaminoxy)acetamides were synthesised as analogues of type A neuroleptic and antipsychotic benzamides, in which the aromatic group is substituted by a (methyleneaminoxy)methyl moiety (C = NOCH2, MAOMM). Theoretical studies were performed in order to verify whether conformational analogies could exist between type A and type B compounds. Type B compounds were tested for their D2-dopaminergic binding affinity which represents a valid indication of their potential neuroleptic and antipsychotic properties. Biological results indicate that the MAOMM is not able to substitute the aromatic group effectively in the field of neuroleptic benzamides. The results are discussed in the light of the structural analogies and the differences between the MAOMM and the aryl.
Synthesis and Biological Activity of Benzaldehyde O-Alkyloximes as Abscisic Acid Mimics (Part 1)
Yoshikawa, Hiromichi,Fujimoto, Eri,Doi, Keiko
, p. 256 - 260 (2007/10/02)
Twenty-four benzaldehyde O-alkyloximes having a carboxylic moiety at the α-position of the oxime-oxygen were prepared as abscisic acid (ABA) mimics.Their effects on some physiological and biochemical processes of selected plant species were investigated in comparison to those of ABA.The mimics exhibited ABA-like activity by inhibiting germination and α-amylase induction.They also induced stomatal closure coupled with a reduction in transpiration.
