3717-33-7

Basic information

• Product Name: (Z)-3-Chlorobenzaldehyde oxime
• Synonyms: (Z)-3-Chlorobenzaldehyde oxime
• CAS NO: 3717-33-7
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58
• Mol File: 3717-33-7.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (Z)-3-Chlorobenzaldehyde oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-Chlorobenzaldehyde oxime(3717-33-7)
• EPA Substance Registry System: (Z)-3-Chlorobenzaldehyde oxime(3717-33-7)

Safety Data

• Hazardous Substances Data: 3717-33-7(Hazardous Substances Data)

Upstream product

• 96-29-7 ethyl methyl ketone oxime 
• 587-04-2 m-Chlorobenzaldehyde 
• 2972-73-8 2-(3-chlorobenzylidene)malononitrile 
• 873-63-2 m-chlorobenzyl alcohol 
• 99-61-6 3-nitro-benzaldehyde 
• 87-91-2 diethyl (2R,3R)-tartrate 
• 14394-72-0 ethyl (E)-2-cyano-3-(3-chlorophenyl)-2-propenoate 
• 3717-33-7 (E)-3-chlorobenzaldehyde oxime 
• 71-43-2 benzene 

Downstream Products

• 3717-33-7 (E)-3-chlorobenzaldehyde oxime 
• 26994-63-8 3-chloro-benzaldehyde (E)-O-(1,1-dioxo-1H-1λ⁶-benzo[d]isothiazol-3-yl)-oxime 
• 587-04-2 m-Chlorobenzaldehyde 
• 141891-20-5 3-Chloro-benzaldehyde O-ethyl-oxime 
• 1416561-53-9 (E)-3-chlorobenzaldehyde O-butyryl oxime 
• 105755-37-1 4-chlorobenzohydroximoyl chloride 
• 141891-36-3 2-[1-(3-Chloro-phenyl)-meth-(E)-ylideneaminooxy]-butyric acid 
• 141891-34-1 2-[1-(3-Chloro-phenyl)-meth-(E)-ylideneaminooxy]-propionic acid 
• 141891-32-9 [1-(3-Chloro-phenyl)-meth-(E)-ylideneaminooxy]-acetic acid 
• 161064-09-1 3-(3-Chloro-phenyl)-5-vinyl-4,5-dihydro-isoxazole 

Relevant articles and documents

Water mediated procedure for preparation of stereoselective oximes as inhibitors of MRCK kinase

Stereoselective aldoximes, preferably Z form have been obtained from α-cyano substituted carbonyl conjugated alkenes. This reaction occurs through Michael addition type reaction followed by retro-Knoevenagel reaction without transition-metal catalysis via C–C bond cleavage. These oximes are evaluated against cancer cell lines employing mechanistic study. Two oximes showed significant cytotoxic activity, which through in silico studies were found to inhibit MRCK Kinase, responsible for metastatic spread of cancer mortality.

A versatile strategy for the synthesis of 4,5-dihydroxy-2,3-pentanedione (DPD) and related compounds as potential modulators of bacterial quorum sensing

Resistance to antibiotics is an increasingly serious threat to global public health and its management translates to significant health care costs. The validation of new Gram-negative antibacterial targets as sources for potential new antibiotics remains a challenge for all the scientists working in this field. The interference with bacterial Quorum Sensing (QS) mechanisms represents a potentially interesting approach to control bacterial growth and pursue the next generation of antimicrobials. In this context, our research is focused on the discovery of novel compounds structurally related to (S)-4,5-dihydroxy-2,3-pentanedione, commonly known as (S)-DPD, a small signaling molecule able to modulate bacterial QS in both Gram-negative and Gram-positive bacteria. In this study, a practical and versatile synthesis of racemic DPD is presented. Compared to previously reported syntheses, the proposed strategy is short and robust: it requires only one purification step and avoids the use of expensive or hazardous starting materials as well as the use of specific equipment. It is therefore well suited to the synthesis of derivatives for pharmaceutical research, as demonstrated by four series of novel DPD-related compounds described herein.

One-pot two-step sequential transformation: Highly efficient construction of o-2,3,5,6-tetrafluorobenzonitrile substituted oximes ethers

A practical variety of o-2,3,5,6-tetrafluorobenzonitrile substituted oximes ethers bearing broad functional groups were synthesized in moderate to good yields. The key highlight of this disclosure involving a one-pot two-step tandem procedure in aqueous media: the in situ formation of aryl aldehydes or ketones oximes followed by the SNAr reaction with pentafluorobenzonitrile via the high selective CF bond cleavage.