1419171-75-7

Upstream product

• 683251-61-8 methyl 2-(2-bromothiophene-3-yl)acetate 
• 6964-21-2 thiophen-3-yl-acetic acid 
• 1419171-74-6 methyl 2-(2-{3-[3-(2-methoxy-2-oxoethyl)thiophen-2-yl]phenyl}thiophen-3-yl)acetate 
• 58414-52-1 thiophen-3-yl-acetic acid methyl ester 

Downstream Products

• 1419169-94-0 5-[4-(carboxymethyl)-5-{3-[3-(carboxymethyl)-5-(5-carboxythiophen-2-yl)thiophen-2-yl]phenyl}thiophen-2-yl]thiophene-2-carboxylic acid 
• 1419169-95-1 2-(2-{3-[3-(carboxymethyl)-5-(4-methanesulfonylphenyl)thiophen-2-yl]phenyl}-5-(4-methanesulfonylphenyl)thiophen-3-yl)acetic acid 
• 1419172-06-7 C₃₄H₃₀O₈S₄ 

Relevant academic research and scientific papers

NOVEL COMPOUNDS AND THEIR USE IN THERAPY

The present invention relates to novel chemical compounds formula (I) (C)n-B-(A)m-B-(C)n (I) wherein m is 0 or 1, and n is independently 0, 1, 2 or 3, A, each B and each C are independently selected from phenylene and five-and six-membered heteroaromatic rings, and for a terminal ring B or C also from bicyclic heteroaromatic fused rings having seven to ten ring members, wherein the bond between at least two of the rings A to C may be replaced by a carbonyl group (-CO-), wherein at least two of the rings A to C are substituted with one or two groups R, and wherein each ring A to C further optionally is substituted with one or two groups R1. The compounds are useful in therapy, especially therapy of a mammal suffering from a disease involving misfolded or aggregated forms of proteins.

NOVEL THIOPHENE COMPOUNDS AND METHOD FOR IN VIVO IMAGING

The present invention relates to novel labelled compounds of formula (I) (C)n-B-(A)m-B-(C)n (I) wherein m is 0 or 1, and n is independently 0, 1, 2 or 3, A, each B and each C are independently selected from phenylene and five- and six-membered heteroaromatic rings, and for a terminal ring B or C also from bicyclic heteroaromatic fused rings having seven to ten ring members, wherein the bond between at least two of the rings A to C may be replaced by a carbonyl group ( -CO- ), wherein at least two of the rings A to C are substituted with one or two groups R, and wherein each ring A to C further optionally is substituted with one or two groups R1, for use in imaging amyloid deposits and aggregated protein in living patients. The invention further relates to imaging methods using labelled or unlabelled compounds of formual I and the use of unlabelled compounds in such methods.