1419174-64-3Relevant academic research and scientific papers
Synthesis of indolines by copper-mediated intramolecular aromatic C-H amination
Takamatsu, Kazutaka,Hirano, Koji,Satoh, Tetsuya,Miura, Masahiro
, p. 3242 - 3249 (2015/03/30)
A Cu(OAc)2-mediated intramolecular aromatic C-H amination proceeds with the aid of a picolinamide-type bidentate coordination group to deliver the corresponding indolines in good yields. The reaction occurs smoothly even under noble-metal-free conditions, and in some cases the use of an MnO2 terminal oxidant renders the process catalytic in Cu. The mild oxidation aptitude of Cu(OAc)2 and/or MnO2 accommodates the formation of electron-rich thiophene-and indole-fused indoline analogues. The Cu-based system can provide an effective approach to various indolines of potent interest in pharmaceutical and medicinal chemistry.
Direct lactonization of 2-arylacetic acids through Pd(II)-catalyzed C-H activation/C-O formation
Yang, Mingyu,Jiang, Xingyu,Shi, Wen-Juan,Zhu, Qi-Lei,Shi, Zhang-Jie
supporting information, p. 690 - 693 (2013/04/10)
Palladium-catalyzed direct lactonization of 2-arylacetic acids through a reaction sequence that includes C-H activation/C-O formation is reported. This method provides a concise and efficient pathway to synthesize fully functionalized benzofuranone derivatives, which are highly relevant to bioactive natural and synthetic products.
