141923-40-2 Usage
Uses
Used in Pharmaceutical Industry:
H-SER-PHE-LEU-LEU-ARG-ASN-NH2 is used as a protease-activated receptor 1 (PAR-1) selective activating peptide for its ability to selectively activate PAR-1 receptors. This activation plays a crucial role in various physiological processes, including blood clotting, inflammation, and cell proliferation. By targeting PAR-1 receptors, this peptide has potential therapeutic applications in treating conditions related to these processes.
Biochem/physiol Actions
Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt (SFLLRN) acts as a protease-activated receptor 1 (PAR-1) specific agonist peptide.
Check Digit Verification of cas no
The CAS Registry Mumber 141923-40-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,9,2 and 3 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 141923-40:
(8*1)+(7*4)+(6*1)+(5*9)+(4*2)+(3*3)+(2*4)+(1*0)=112
112 % 10 = 2
So 141923-40-2 is a valid CAS Registry Number.
141923-40-2Relevant academic research and scientific papers
Development of a Potent Thrombin Receptor Ligand
Feng, Dong-Mei,Veber, Daniel F.,Connolly, Thomas M.,Condra, Cindra,Tang, Mei-Jy,Nutt, Ruth F.
, p. 4125 - 4130 (2007/10/03)
The N-terminal thrombin receptor peptide H-Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-OH (1) fully activates the thrombin receptor with an EC50 of 10 μM.Structural features in the tetradecapeptide which are responsible for receptor activation have been elucidated.Agonist potency has been enhanced 1000-fold with the design of the shortened peptide H-Ala-Phe(p-F)-Arg-Cha-HArg-Tyr-NH2 (56).This analog exhibits an EC50 of 0,01 μM and is the most potent agonist for receptor activation reported to date.The monoiodinated derivative H-Ala-Phe(p-F)-Arg-Cha-HArg-Tyr(3-I)-NH2 (59) exhibits an EC50 of 0.03 μM, a level sufficient for development of a radioligand.
