141937-91-9

Upstream product

• 141708-71-6 (Z)-1,1,1-trifluoro-2-ethoxy-5-phenyl-2-pentene 
• 637-59-2 1-Bromo-3-phenylpropane 
• 7484-37-9 (3-phenylpropyl)triphenylphosphonium bromide 

Downstream Products

• 141937-95-3 1,1,1-Trifluoro-3-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-5-phenyl-pentan-2-one 
• 141937-94-2 3-Dibenzylamino-1,1,1-trifluoro-5-phenyl-pentan-2-one 
• 177747-67-0 1,1,1-trifluoro-5-phenyl-3-phenylthio-2-propanone 
• 141938-02-5 1,1,1-Trifluoro-2-hydroxy-5-phenyl-pentan-3-one 
• 141938-03-6 1,1,1-Trifluoro-3-hydroxy-5-phenyl-pentan-2-one 
• 141937-97-5 (2R,3S)-1,1,1-Trifluoro-5-phenyl-3-piperazin-1-yl-pentan-2-ol 
• 141938-01-4 (2R,3S)-1,1,1-Trifluoro-5-phenyl-3-(4-phenyl-piperazin-1-yl)-pentan-2-ol 
• 141938-00-3 (2R,3S)-1,1,1-Trifluoro-3-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-5-phenyl-pentan-2-ol 
• 141937-99-7 (2S,3R)-3-Dibenzylamino-1,1,1-trifluoro-5-phenyl-pentan-2-ol 
• 141937-98-6 (2R,3S)-1,1,1-Trifluoro-3-morpholin-4-yl-5-phenyl-pentan-2-ol 

Relevant academic research and scientific papers

A new and efficient synthesis of α-bromoalkyl perfluoroalkyl ketones via opening of epoxides

Regioselective ring opening of various substituted perfluoroepoxy ethers was achieved with magnesium bromide, leading to new α-bromofluoroalkyl ketones in good yields.

A versatile synthesis of amino trifluoromethyl ketones and alcohols

A short, selective and general route to α-amino trifluoromethyl ketones and corresponding alcohols is described via an easy epoxidation of 1-CF3 enol ethers followed by an opening with various secondary amines.