141939-07-3Relevant academic research and scientific papers
An unprecedented protocol for the synthesis of 3-hydroxy-3-phenacyloxindole derivatives with indolin-2-ones and α-substituted ketones
Bai, Mei,You, Yong,Chen, Yong-Zheng,Xiang, Guang-Yan,Xu, Xiao-Ying,Zhang, Xiao-Mei,Yuan, Wei-Cheng
, p. 1395 - 1401 (2016/02/03)
An unprecedented reaction between indolin-2-ones and α-substituted ketones has been developed. Using this protocol, a wide range of biologically important 3-hydroxy-3-phenacyloxindole derivatives could be obtained in good yield (up to 93%) under mild reaction conditions. A possible mechanism of this reaction was tentatively proposed based on some control experiments and MS spectrometry analysis.
Molecular sieve mediated decarboxylative Mannich and aldol reactions of β-ketoacids
Zhong, Fangrui,Jiang, Chunhui,Yao, Weijun,Xu, Li-Wen,Lu, Yixin
supporting information, p. 4333 - 4336 (2013/07/26)
A molecular sieve mediated decarboxylative Mannich reaction of β-ketoacids with sulfonyl imines is reported; this protocol leads to an efficient preparation of synthetically useful β-amino ketones. An analogous molecular sieve promoted decarboxylative aldol reaction between β-ketoacids and isatins is also described, which affords bioactive 3-substituted-3-hydroxy-oxindoles in excellent yields.
