141958-08-9Relevant academic research and scientific papers
The Discovery of (2S,3S)-cis-2-(diphenylmethyl)-N--1-azabicyclooctan-3-amine as a Novel, Nonpeptide Substance P Antagonist
Lowe, John A.,Drozda, Suzan E.,Snider, R. Michael,Longo, Kelly P.,Zorn, Stevin H.,et al.
, p. 2591 - 2600 (1992)
We describe the structure-activity relationship development of a series of quinuclidines which culminated in the first potent, selective, nonpeptide substance P (SP) antagonist, (2S,3S)-cis-2-(diphenylmethyl)-N--1-azabicyclo2.2.2
Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
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, (2008/06/13)
Azabicyclo[2.2.2]octan-3-imines of the general formula STR1 wherein R1, R2 and R3 are as defined herein are prepared by reacting a compound of the formula STR2 with a compound of the formula STR3 wherein A is MgCl, MgBr or Li.
