The Discovery of (2S,3S)-cis-2-(diphenylmethyl)-N--1-azabicyclooctan-3-amine as a Novel, Nonpeptide Substance P Antagonist

DOI: 10.1021/jm00092a009

Source and publish data:

Journal of Medicinal Chemistry p. 2591 - 2600 (1992)

Update date:2022-08-04

Topics:

Authors:

Lowe, John A.

Drozda, Suzan E.

Snider, R. Michael

Longo, Kelly P.

Zorn, Stevin H.

et al. et al.

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Article abstract of DOI:10.1021/jm00092a009

We describe the structure-activity relationship development of a series of quinuclidines which culminated in the first potent, selective, nonpeptide substance P (SP) antagonist, (2S,3S)-cis-2-(diphenylmethyl)-N-<(2-methoxyphenyl)methyl>-1-azabicyclo<2.2.2

Full text of DOI:10.1021/jm00092a009

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