The Discovery of (2S,3S)-cis-2-(diphenylmethyl)-N--1-azabicyclooctan-3-amine as a Novel, Nonpeptide Substance P Antagonist

DOI: 10.1021/jm00092a009

Source and publish data:

Journal of Medicinal Chemistry p. 2591 - 2600 (1992)

Update date:2022-08-04

Topics:

Authors:

Lowe, John A.

Drozda, Suzan E.

Snider, R. Michael

Longo, Kelly P.

Zorn, Stevin H.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00092a009

We describe the structure-activity relationship development of a series of quinuclidines which culminated in the first potent, selective, nonpeptide substance P (SP) antagonist, (2S,3S)-cis-2-(diphenylmethyl)-N-<(2-methoxyphenyl)methyl>-1-azabicyclo<2.2.2

Full text of DOI:10.1021/jm00092a009

Products guided by the article

Product name:2-(diphenylmethyl)-N-<(2-methoxyphenyl)methyl>-1-azabicyclo<2.2.2>octan-3-imine

Cas No:141958-08-9

R&D Labs maybe for 141958-08-9

Nanjing Samwon International Limited

Contact:+86-25-84873444

Address:1108, BLDG B, New Century Plaza, No 1, South Taiping Rd.,
Zhushan County Tianxin Pharmaceutical & Chemical Co., Ltd.

Contact:0086-719-4224892

Address:Tutang Road, Chengguan Town, Zhushan County, Hubei Province
SICHUAN ZHONGBANG NEW MATERIAL CO., LTD

website:http://www.zhongbangst.com

Contact:86-830-2585019

Address:sichuan,china
Wuhan Yitongtai Science and Technology Co.,Ltd.

Contact:+86-27-88933550

Address:27th Fl. Bldg. 1, Shuian International Mansion, Heping Ave, Wuhan, Hubei, China
Jiangxi Hessence Chemicals Co., Ltd.

Contact:+86 796 3511924

Address:Chengxi Industrial Park, Jishui County, Jiangxi Province 331600 China.

Relevant to this article

Doi:10.1021/ja00975a028
(1966)
The addition of Organolithiums to Ketenethioacetals: A new cyclopentannulation sequence leading to indanes

Doi:10.1016/S0040-4039(00)78885-X
(1992)
Synthesis of quinolones by nickel-catalyzed cycloaddition via elimination of nitrile

Doi:10.1021/ol303546p
(2013)
Efficient synthesis of silylated 2,2-difluorostyrene derivatives through Suzuki-Miyaura cross-coupling of 2,2-difluoro-1-iodo-1-silylethenes

Doi:10.1039/c2ob27221k
(2013)
The Role of the acidity of N-heteroaryl sulfonamides as inhibitors of Bcl-2 family protein-protein interactions

Doi:10.1021/ml300321d
(2013)
The differing influence of halides upon supramolecular aggregation through C-X...π interactions in the crystal structures of (5-methyl-1-(4-X- arylamino)-1H-1,2,3-triazol-4-yl)methanol derivatives, X = H, F and Cl

Doi:10.1039/c2ce25841b
(2012)

Article Doi