1419590-34-3Relevant academic research and scientific papers
Development of a Large-Scale Route to an MCH1 Receptor Antagonist: Investigation of a Staudinger Ketene-Imine Cycloaddition in Batch and Flow Mode
Karlsson, Staffan,Bergman, Rolf,L?fberg, Christian,Moore, Peter R.,Pontén, Fritiof,Tholander, Joakim,S?rensen, Henrik
, p. 2067 - 2074 (2016/01/08)
A practical large-scale route to an MCH1 receptor antagonist is described. A Staudinger β-lactam synthesis of an imine and an in situ generated ketene was utilized as a key step for the preparation of a spiro-azetidine building block. The reaction was demonstrated in both batch and flow mode and a comparison of these techniques is described.
AZETIDINE DERIVATIVES FOR TREATMENT OF MELANIN RELATED DISORDERS
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, (2013/03/26)
Disclosed herein are azetidinyl compounds of formula I, as described herein, pharmaceutical compositions comprising an azetidinyl compound, and a method of using an azetidinyl compound in the treatment or prophylaxis of a melanin- concentrating hormone related disease or condition.
